Special Issue "The Role of Heat Shock Proteins: From Molecular Mechanisms to Therapeutics"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2019).
Interests: cell stress and chaperones; heat shock proteins; cancer; malaria
Many heat shock proteins (HSPs) are essential to survival, and play a critical role as molecular chaperones in maintaining cellular proteostasis through the integration of protein folding and degradation pathways. There have been extensive advances in our understanding of the mechanism by which co-chaperones regulate molecular chaperones. However, it is becoming generally accepted that HSPs have additional cellular functions beyond their role in proteostasis, and we are only just beginning to understand their biological function from a whole-of-organism perspective. HSPs are also linked to a range of different human disorders (e.g., cancer, diabetes, autoimmune disease, neurodegeneration, muscular dystrophies, and chronic heart failure) and infectious diseases (e.g., viral, microbial, and parasitic infections including malaria and trypanosomiasis), with changes in their expression and localisation linked to disease pathology. Contributions to this Special Issue will provide new insights into the mechanism of action of HSPs, deepen our understanding of their biological role in health and disease, and reveal novel HSP-based therapeutic opportunities.
Prof. Dr. Gregory Blatch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- heat shock proteins
- molecular chaperones
- protein folding
- chronic diseases
- infectious diseases