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Special Issue "Hedgehog Signaling 3.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Prof. Dr. Tsuyoshi Shimo
E-Mail Website
Guest Editor
Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Ishikari-Tobetsu, Hokkaido 061-0293, Japan
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Hedgehog signaling pathways govern complex developmental processes, including stem-cell maintenance, proliferation, differentiation, and patterning. However, hedgehog signaling is frequently activated in various human cancers. Several recent studies have shown that the aberrant activation of hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, drug resistance of multiple cancers, and survival rate.

Recent evidences indicate that Hh signaling is involved, through different mechanisms, in human malignancies where it promotes growth, enables proliferation of tumor stem cells and regulates tumor-stroma interaction. A ligand independent Shh pathway activation has been described in familial cancers, such as basal cell carcinoma, medulloblastoma and rhabdomyosarcoma, as a consequence of genetic aberrations, targeting mainly the Ptch inhibitory receptor. Ligand-independent non-canonical Shh pathway activation has been reported in several tumor models as a result of a crosstalk with different tumorigenic pathways. Finally, ligand-dependent autocrine or paracrine activation has also been described. Research articles, reviews and communications on every aspect of Hh signaling in cancer and other human diseases as well as on the role of Hh moleculs as diagnostic, prognostic and therapeutic targets are invited.

This Special Issue focuses on several aspects of hedgehog signaling research, and we invite contributions of reviews and/or original papers reporting on the recent efforts in the field of hedgehog signaling.

Prof. Dr. Tsuyoshi Shimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hedgehog
  • tumor microenvironment
  • metastasis
  • angiogenesis
  • cancer stem cell
  • tumor–stroma interaction
  • target genes
  • primary cilia
  • hedgehog signaling pathway
  • hedgehog signaling inhibitors
  • targeted cancer therapy
  • cancer treatment resistance
  • immune surveillance

Published Papers

This special issue is now open for submission.
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