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Special Issue "Hematopoietic System under Physiological Conditions and Following Hematopoietic Reconstitution or Stress"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Alexander V. Belyavsky
E-Mail Website
Guest Editor
Laboratory of Stem and Progenitor Cell Biology, Engelhardt Institute of Molecular Biology RAS, Vavilov Str. 32, 119991 Moscow, Russia

Special Issue Information

The seminal work of Till & McCulloch on CFU-Ss in 1961 proved the remarkable conjecture of Maximov some 50 years earlier on the existence of hematopoietic stem cells (HSCs) and laid foundations for their quantitative analysis. Ever since then, in this field, leading labs have dedicated significant effort to the progressive refinement of HSC features and physical isolation of more defined HSC and progenitor cell populations. This was mainly achieved with the use of monoclonal antibodies developed against various blood cell subsets, whereas transplantation into irradiated hosts has been accepted as a gold standard for quantitative functional characterization of purified cell fractions.

These efforts resulted in the appearance of a hierarchical, pyramidal model of blood cell differentiation, which presented a clear-cut scheme of stages that HCSs follow to produce huge amounts of differentiated blood cells to meet the physiological needs of an organism. The hierarchical model provided a very rational and logical explanation of how the hematopoietic system works. Alas, nature rarely follows human reasoning, and this model has not become an exception. The recent introduction of new sophisticated techniques such as single-cell transplantation, specific cell lineage/stage marking using transgenic mouse lines, cell barcoding, next-generation sequencing, single-cell transcriptome analysis, and related bioinformatics tools demonstrated that patterns of HSC differentiation are likely more complex than previously thought. Moreover, recent studies demonstrate that hematopoiesis established in irradiated animals using transplanted cell fractions, and the physiological steady-state hematopoiesis taking place in non-treated animals, not only formally differ from each other, but represent fairly different physiological systems, in which the same cell subsets may demonstrate contrasting behaviors. Given the currently accepted notion that the behavior of HSCs is determined to a large extent by the niches in which they reside, this difference may be partly explained by the irradiation damage sustained by the niche components and, possibly, peculiarities of homing to niches of various cell subsets in different physiological states. As suggested by some recent indirect data, it cannot be taken for granted that HSCs detached from their niches and subjected to significant stress during cell sorting do not substantially change their properties. If such a change occurs, this may warrant a significant revision of the results of previous experiments with transplanted sorted cells.

The true size of the “iceberg” of the complexity of the hematopoietic system is just becoming apparent and, obviously, many more studies using the most advanced techniques are needed to obtain accurate and consistent knowledge of how the hematopoietic system work. In this Special Issue, we invite researchers to submit original research articles on HSC/progenitor cells, hematopoietic microenvironment, and hematopoiesis under different conditions, or reviews on the last developments in these fields.

Dr. Alexander V. Belyavsky
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hematopoietic stem/progenitor cells
  • hematopoietic differentiation
  • hematopoietic niches
  • niche-HSC/progenitor cell interactions
  • steady-state hematopoiesis
  • reconstituted hematopoiesis
  • hematopoietic stress response
  • cell fate tracing

Published Papers (1 paper)

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Hematopoiesis during Ontogenesis, Adult Life, and Aging
Int. J. Mol. Sci. 2021, 22(17), 9231; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179231 - 26 Aug 2021
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In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two stem cell types and their descendants interact. The descendants of HSCs supply the body with all the [...] Read more.
In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two stem cell types and their descendants interact. The descendants of HSCs supply the body with all the mature blood cells, while MSCs give rise to stromal cells that form a niche for HSCs and regulate the process of hematopoiesis. The studies of hematopoiesis were initially based on morphological observations, later extended by the use of physiological methods, and were subsequently augmented by massive application of sophisticated molecular techniques. The combination of these methods produced a wealth of new data on the organization and functional features of hematopoiesis in the ontogenesis of mammals and humans. This review summarizes the current views on hematopoiesis in mice and humans, discusses the development of blood elements and hematopoiesis in the embryo, and describes how the hematopoietic system works in the adult organism and how it changes during aging. Full article
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