Special Issue "Protective and Detrimental Role of Heme Oxygenase-1: 2021"
Deadline for manuscript submissions: 31 October 2021.
Interests: oxygen and nitric oxide toxicity and cellular defenses in various pathophysiological conditions; stress-related diseases; evaluation of activity of natural drugs and new synthetic compounds; antioxidant defences; heme oxygenase
Special Issues and Collections in MDPI journals
Heme oxygenase (HO) is the enzyme that catalyzes the regioselective oxidative catabolism of heme, with the simultaneous release of carbon monoxide (CO), ferrous iron (Fe2+), and biliverdin, which is then reduced to bilirubin. The first consequence of this enzymatic activity is a cyto-protective effect in various stress-related conditions. Two main isoforms of heme oxygenase are present in humans: HO-1, inducible, and HO-2, constitutive. HO-1 may be induced in many organs and tissues by a variety of stimuli, such as the same substrate heme, heat shock, ROS and stressful conditions. Therefore, its critical role is cell protection against such insults. HO-1 may be both up- and down-regulated. During the past decade, a large number of studies have been carried out to delineate the diverse roles of HO-1 in inflammatory, neurodegenerative and other stress conditions. Due to its cyto-protective effects, HO-1 up-regulation may be useful in many stress-related diseases. On the contrary, HO-1 over-expression may contribute to tissue injury under certain unfavorable conditions such as neurodegeneration and carcinogenesis. Therefore, HO-1 inhibition mediated by natural or synthetic compounds may be useful.
The Special Issue, “Protective and detrimental role of heme oxygenase-1”, of the International Journal of Molecular Sciences will include a selection of original research papers and reviews aimed to understanding the dual role (protective and detrimental) of HO-1 and the signaling pathway involved. Moreover, original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression will help make HO-1 a potential therapeutic target for the amelioration of various diseases.
Prof. Valeria Sorrenti
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- oxidative stress
- natural compounds
- HO-1 inducers
- HO-1 inhibitors