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Special Issue "Protective and Detrimental Role of Heme Oxygenase-1: 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Valeria Sorrenti
Guest Editor
Department of Drug Sciences, Universita degli Studi di Catania, Catania, Italy
Interests: oxygen and nitric oxide toxicity and cellular defenses in various pathophysiological conditions; stress-related diseases; evaluation of activity of natural drugs and new synthetic compounds; antioxidant defences; heme oxygenase
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Heme oxygenase (HO) is the enzyme that catalyzes the regioselective oxidative catabolism of heme, with the simultaneous release of carbon monoxide (CO), ferrous iron (Fe2+), and biliverdin, which is then reduced to bilirubin. The first consequence of this enzymatic activity is a cyto-protective effect in various stress-related conditions. Two main isoforms of heme oxygenase are present in humans: HO-1, inducible, and HO-2, constitutive. HO-1 may be induced in many organs and tissues by a variety of stimuli, such as the same substrate heme, heat shock, ROS and stressful conditions. Therefore, its critical role is cell protection against such insults. HO-1 may be both up- and down-regulated. During the past decade, a large number of studies have been carried out to delineate the diverse roles of HO-1 in inflammatory, neurodegenerative and other stress conditions. Due to its cyto-protective effects, HO-1 up-regulation may be useful in many stress-related diseases. On the contrary, HO-1 over-expression may contribute to tissue injury under certain unfavorable conditions such as neurodegeneration and carcinogenesis. Therefore, HO-1 inhibition mediated by natural or synthetic compounds may be useful.

The Special Issue, “Protective and detrimental role of heme oxygenase-1”, of the International Journal of Molecular Sciences will include a selection of original research papers and reviews aimed to understanding the dual role (protective and detrimental) of HO-1 and the signaling pathway involved. Moreover, original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression will help make HO-1 a potential therapeutic target for the amelioration of various diseases.

Prof. Valeria Sorrenti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • HO-1
  • oxidative stress
  • natural compounds
  • HO-1 inducers
  • HO-1 inhibitors

Published Papers

This special issue is now open for submission.
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