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Hormones-Dependent Cancers: New Aspects on Biochemistry and Molecular Pathology 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 2561

Special Issue Editor

Special Issue Information

Dear Colleagues,

It is well-known that breast and prostate cancers are related to female and male hormones, respectively. Recently, it has been established that male steroid hormones, such as androgen, play an important role in female breast cancer progression. For approximately a dozen years, the possibility of anti-estrogen therapy for both female and male non-small lung carcinoma patients has been a significant area of research. In addition, the peptide hormones released by psychological stress directly stimulate growth signals in solid cancers, such as ovarian and endometrial cancers. Research into hormone-dependent cancers continues to progress at a rapid pace.
This Special Issue of the International Journal of Molecular Sciences entitled “Hormone-Dependent Cancers: New Aspects of Biochemistry and Molecular Pathology 3.0”, will focus on recent advances in hormone and cancer research, such as the molecular action of hormone receptors, biochemical analysis of steroid or peptide hormones, growth or invasive signals of hormone-related cancers, and mechanisms of resistance of endocrine therapy. Contributions on these or related topics are welcome, including original research and full- and mini-reviews. Postdocs, Ph.D. students, and young researchers are all very welcome to contribute.

Dr. Yasuhiro Miki
Guest Editor

Manuscript Submission Information

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Keywords

  • Hormone-related cancer
  • Endocrine/intracrine
  • Breast
  • Prostate
  • Endometrium
  • Ovary
  • Endocrine organs
  • Female and male hormones
  • Growth hormones
  • Steroid hormones
  • Peptide hormones
  • Hormone receptors
  • Biochemical analysis
  • Pathophysiology
  • Molecular biology

Published Papers (1 paper)

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Research

13 pages, 554 KiB  
Article
Circulating Vitamin D Levels and DNA Repair Capacity in Four Molecular Subtypes of Women with Breast Cancer
by Carmen Ortiz-Sánchez, Jarline Encarnación-Medina, Ralphdy Vergne, Luis Padilla and Jaime Matta
Int. J. Mol. Sci. 2020, 21(18), 6880; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186880 - 19 Sep 2020
Cited by 2 | Viewed by 2287
Abstract
Vitamin D regulates estrogen synthesis among other mechanisms involved in breast cancer (BC) development; however, no evidence has been found regarding its relationship with DNA repair capacity (DRC). Therefore, the objective of this study was to elucidate whether DRC levels are linked with [...] Read more.
Vitamin D regulates estrogen synthesis among other mechanisms involved in breast cancer (BC) development; however, no evidence has been found regarding its relationship with DNA repair capacity (DRC). Therefore, the objective of this study was to elucidate whether DRC levels are linked with plasma 25(OH)D levels. BC cases and controls were selected from our BC cohort. DRC levels were assessed in lymphocytes through the host-cell reactivation assay. 25(OH)D levels were measured using the UniCel DxI 600 Access Immunoassay System. BC cases (n = 91) showed higher 25(OH)D levels than the controls (n = 92) (p = 0.001). When stratifying BC cases and controls into low and high DRC categories, BC cases with low DRC (n = 74) had the highest 25(OH)D levels (p = 0.0001). A positive correlation between 25(OH)D and DRC levels was found for the controls (r = 0.215, p = 0.043) while a negative correlation was found for BC cases (r = −0.236, p = 0.026). Significant differences in 25(OH)D levels were observed when stratifying by molecular subtypes (p = 0.0025). Our study provides evidence of a link between 25(OH)D and DRC in BC along with a description of to how 25(OH)D levels vary across subtypes. The positive correlation observed in the control group suggests that 25(OH)D contributes differently to DRC levels once the malignancy is developed. Full article
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