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Intercellular Communications in Tumor Microenvironment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2550

Special Issue Editors

Laboratoire STIM, ERL7003 CNRS-Université de Poitiers, 1 rue G. Bonnet–TSA 51 106, 86073 Poitiers, France
Interests: Tumor environment; Intercellular Communication; Gap Junction; Hemichanel; Connexin43; Glioblastoma; Cell Migration and Invasion; Invadopodia
CoMeT Laboratory, UR 24344, Université de Poitiers, 86073 Poitiers, France
Interests: gap junctions; connexins; intercellular communication; cancer; glioma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Within the tumor microenvironment, intercellular communication is a complex network that promotes cancer cell invasion and metastasis. In this particular environment, tumor cells communicate not only with each other but also with surrounding stroma cells or any other cell type present such as macrophages and endothelial cells through various forms that can be either direct (gap junctions) or indirect by the exchange of secreted factors (growth factors, cytokines, etc.).

Recently, other communication modalities emerged such as exosomes or tunneling nanotubes. The exosomes, nanometric-sized vesicles (30 to 100 nm in diameter), are secreted by cells of the tumor microenvironment. Taken up by other cells, exosome cargoes (proteins, glycans, lipids, metabolites, RNA and DNA) are transferred to target cells and influence their gene expression and behavior. Tunneling nanotubes are cytoplasmic extensions that facilitate the transport, between tumor cells and stromal cells, of cargoes (microRNAs, mitochondria, etc.), which can be responsible for cancer cell invasion, metastasis, or resistance to chemotherapy.

Therefore, through its various forms, intercellular communication is essential for tumor progression. This special issue will allow focusing on these different modalities of intercellular communication within the tumor microenvironment, in order to better diagnose tumors, classify them, and predict the outcome of treatments.

Dr. Norah Defamie
Prof. Marc Mesnil
Guest Editors

Manuscript Submission Information

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Keywords

  • Intercellular Communication
  • Soluble factors
  • Gap junctions
  • Extracellular vesicles or Exosomes
  • Tunneling Nanotubules

Published Papers (1 paper)

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Research

14 pages, 2010 KiB  
Article
Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells
by Patricia Torres-Barrera, Dafne Moreno-Lorenzana, José Antonio Alvarado-Moreno, Elena García-Ruiz, Cesar Lagunas, Hector Mayani and Antonieta Chávez-González
Int. J. Mol. Sci. 2022, 23(18), 10326; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms231810326 - 07 Sep 2022
Viewed by 2043
Abstract
Chronic Myeloid Leukemia (CML) originates in a leukemic stem cell that resides in the bone marrow microenvironment, where they coexist with cellular and non-cellular elements. The vascular microenvironment has been identified as an important element in CML development since an increase in the [...] Read more.
Chronic Myeloid Leukemia (CML) originates in a leukemic stem cell that resides in the bone marrow microenvironment, where they coexist with cellular and non-cellular elements. The vascular microenvironment has been identified as an important element in CML development since an increase in the vascularization has been suggested to be related with poor prognosis; also, using murine models, it has been reported that bone marrow endothelium can regulate the quiescence and proliferation of leukemic stem and progenitor cells. This observation, however, has not been evaluated in primary human cells. In this report, we used a co-culture of primitive (progenitor and stem) CML cells with endothelial colony forming cells (ECFC) as an in vitro model to evaluate the effects of the vascular microenvironment in the leukemic hematopoiesis. Our results show that this interaction allows the in vitro maintenance of primitive CML cells through an inflammatory microenvironment able to regulate the proliferation of progenitor cells and the permanence in a quiescent state of leukemic stem cells. Full article
(This article belongs to the Special Issue Intercellular Communications in Tumor Microenvironment)
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