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Special Issue "Intrinsically Disordered Proteins (IDPs) 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Josephine C. Ferreon
E-Mail Website
Guest Editor
Baylor College of Medicine, Department of Pharmacology and Chemical Biology, Houston, TX 77030, USA
Interests: NMR spectroscopy; intrinsically disordered proteins; stem cell biology; protein structure and function; post-translational modifications; macromolecular assembly; biomolecular phase transitions
Special Issues, Collections and Topics in MDPI journals
Dr. Allan Chris M. Ferreon
E-Mail Website
Guest Editor
Baylor College of Medicine, Department of Pharmacology and Chemical Biology, Houston, TX, USA
Interests: single molecule biophysics; fluorescence spectroscopy; molecular mechanisms of neurodegenerative disorders; intrinsically disordered proteins; protein folding and misfolding; protein–ligand interactions; biomolecular phase transitions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The classic protein structure–function paradigm has shifted in this millennium with the emergence of a new class of proteins known as intrinsically disordered proteins (IDPs)—proteins that are either entirely unstructured or contain a significant region of disorder. Their function is linked to their conformational flexibility, with many IDPs acting as “hubs” that interact with multiple molecular binding partners to regulate biological functions such as transcription, signal transduction, and intracellular trafficking. A vast number of IDPs are also capable of liquid–liquid phase separation (LLPS), a driving force behind membrane=less organelle (MLO) formation.

The promiscuous nature of IDP interactions increases the chance for misfolding; for example, a significant number of neurodegenerative disease-linked proteins are IDPs, and their aggregation results in the amyloidal fibrils observed in patient neurons. Misregulation of IDPs also leads to their dysfunction, as mutations and post-translational modifications lead to altered molecular interactions that translate to cancer and other diseases.

This Special Issue includes papers contributing to the field of the function and dysfunction of IDPs.

Prof. Dr. Josephine Ferreon
Prof. Dr. Allan Chris M. Ferreon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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