ijms-logo

Journal Browser

Journal Browser

Ischemic Heart Disease 2.0: From Bench to Bedside

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 33013

Special Issue Editor

Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy
Interests: heart failure; acute coronary syndrome; pulmonary hypertension; coronary microvascular dysfuntion; coronary artery disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ischemic heart disease (IHD) is a common disease that, globally, represents an important problem for individuals and healthcare resources. The global problems that IHD causes is not a recent event insofar as the burdens caused by IHD have been known for decades—and researched for nearly the same period of time. For these reasons, an enhanced understanding of its pathophysiology is needed. By convention, IHD is associated with the presence of an atherosclerotic plaque that is able to limit the flow in large-medium sized coronary arteries. Nevertheless, several findings suggest a more complex pathophysiology of IHD. At this time, there is no well-defined assessment of myocardial ischemia pathophysiology. To better examine this complicated disease and to provide evidences and perspective, this Special Issue of IJMS is interested in articles that provide insights into the pathophysiology of IHD. In particular, this Special Issue will focus on researches on all the pathophysiological aspects of IHD, ranging from coronary artery disease (CAD) to coronary microvascular disease (CMD). In fact, IHD is a complex and multifaceted syndrome and its pathophysiology includes different pieces of a single puzzle, including factors as atherosclerosis, inflammation, plaque activation, vasospasm, as well as microcirculation dysfunction raised by abnormalities in endothelium, mitochondria, extravascular forces, redox-signaling, ion channels, myocardium-blood flow cross-talk mismatch, and so on. Specifically, original articles reporting completely new results or reviews of current literature on these aspects of the disease will be taking into account. The Special Issue “Ischemic Heart Disease 2.0: From Bench to Bedside” aims to focus on both basic science and translational research, as well as clinical evidence in order to have a more complete comprehension of the pathophysiology of IHD, considering all aspects of this complex puzzle.

Prof. Dr. Francesco Fedele
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coronary artery disease
  • Microvascular dysfunction
  • Myocardial ischemia
  • Myocardial infarction
  • Acute coronary syndrome

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

30 pages, 2395 KiB  
Review
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction
by Paolo Severino, Andrea D'Amato, Mariateresa Pucci, Fabio Infusino, Francesco Adamo, Lucia Ilaria Birtolo, Lucrezia Netti, Giulio Montefusco, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, William M. Chilian and Francesco Fedele
Int. J. Mol. Sci. 2020, 21(21), 8118; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21218118 - 30 Oct 2020
Cited by 144 | Viewed by 32590
Abstract
Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large–medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for [...] Read more.
Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large–medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction. Full article
(This article belongs to the Special Issue Ischemic Heart Disease 2.0: From Bench to Bedside)
Show Figures

Figure 1

Back to TopTop