ijms-logo

Journal Browser

Journal Browser

Special Issue "Mechanisms of Insulin Resistance and Adipose Tissue Dysfunction"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 17 December 2021.

Special Issue Editor

Prof. Dr. Jean-françois Tanti
E-Mail Website
Guest Editor
Université Côte D'Azur, INSERM, C3M, Team “Cellular and Molecular Physiopathology of Obesity”, 06204 Nice, France
Interests: obesity, type 2 diabetes; metabolic syndrome; insulin resistance; adipose tissue; insulin signaling; adipose tissue inflammation

Special Issue Information

Dear Colleagues,

International Journal of Molecular Sciences (ISSN 1422-0067, IF 4.556) is currently running a Special Issue focused on "Mechanisms of Insulin Resistance and Adipose Tissue Dysfunction". Prof. Jean-François Tanti is serving as Guest Editor for this Issue. Based on your excellent expertise, we would be thrilled if you could submit a paper to this Issue.

Insulin resistance (IR) is defined as the impaired intracellular signaling of endogenous and exogenous insulin. IR is a major key player in those metabolic derangements that characterize pathological conditions (e.g., diabesity and metabolic syndrome). Adipocyte and adipose tissue dysfunction belong to the primary defects in obesity and may link obesity to several health problems, including increased risk of insulin resistance, type 2 diabetes, and fatty liver disease.

This Special Issue focuses on the study of the mechanisms of insulin resistance and adipose tissue dysfunction in obesity and type 2 diabetes. Potential topics include but are not limited to decipher the cellular and molecular mechanisms involved in insulin resistance, and the pathophysiological mechanisms connecting adipose tissue dysfunction to the development of insulin resistance, type 2 diabetes, or fatty liver. We warmly welcome original papers and reviews on this widely discussed topic.

Prof. Dr. Jean-françois Tanti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insulin resistance
  • obesity
  • type 2 diabetes
  • adipose tissue dysfunction
  • white adipose tissue (WAT)

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
TNFSF14-Derived Molecules as a Novel Treatment for Obesity and Type 2 Diabetes
Int. J. Mol. Sci. 2021, 22(19), 10647; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910647 - 30 Sep 2021
Viewed by 703
Abstract
Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with glucose intolerance and insulin resistance, often culminating in Type 2 Diabetes (T2D). Importantly, our team has recently shown that the TNF superfamily (TNFSF) member protein, TNFSF14, [...] Read more.
Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with glucose intolerance and insulin resistance, often culminating in Type 2 Diabetes (T2D). Importantly, our team has recently shown that the TNF superfamily (TNFSF) member protein, TNFSF14, has been reported to protect against high fat diet induced obesity and pre-diabetes. We hypothesized that mimics of TNFSF14 may therefore be valuable as anti-diabetic agents. In this study, we use in silico approaches to identify key regions of TNFSF14 responsible for binding to the Herpes virus entry mediator and Lymphotoxin β receptor. In vitro evaluation of a selection of optimised peptides identified six potentially therapeutic TNFSF14 peptides. We report that these peptides increased insulin and fatty acid oxidation signalling in skeletal muscle cells. We then selected one of these promising peptides to determine the efficacy to promote metabolic benefits in vivo. Importantly, the TNFSF14 peptide 7 reduced high fat diet-induced glucose intolerance, insulin resistance and hyperinsulinemia in a mouse model of obesity. In addition, we highlight that the TNFSF14 peptide 7 resulted in a marked reduction in liver steatosis and a concomitant increase in phospho-AMPK signalling. We conclude that TNFSF14-derived molecules positively regulate glucose homeostasis and lipid metabolism and may therefore open a completely novel therapeutic pathway for treating obesity and T2D. Full article
(This article belongs to the Special Issue Mechanisms of Insulin Resistance and Adipose Tissue Dysfunction)
Show Figures

Figure 1

Back to TopTop