Journal Browser

Journal Browser

Special Issue "Innate Immunity Paroxysm in Neurodegenerative Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 December 2020).

Special Issue Editors

Prof. Dr. Michelino Di Rosa
E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy
Interests: neurodegenerative disease; bioinformatics; bhitinases; innate immunity; macrophages; dendritic cells
Special Issues and Collections in MDPI journals
Dr. Cristina Sanfilippo
Guest Editor
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Dr. Loretta Giuliano
Guest Editor
Department G.F. Ingrassia, Section of Neurosciences, University of Catania, Italy

Special Issue Information

Dear Colleagues,

Neuroinflammation is the physiopathological mechanism activated by the CNS in response to trauma, infections, and/or neurodegenerative diseases. During neuroinflammation, the main protagonists are cellular and molecular immune components, such as the innate immunity resident cells (microglia), recruited lymphocytes and macrophages, cytokines, complement, and pattern-recognition receptors. The local innate immune response is based on the recognition of non-self and altered self-patterns by molecules and receptors expressed by microglia but also present in astrocytes, oligodendrocytes, and neurons. These pro-inflammatory mediators are either produced locally within the CNS or recruited from the peripheral system following disruption of the blood–brain barrier. All these elements constitute the immunological environment present in the CNS. The alteration of the balance between the activation and deactivation processes of the resident immunity determines continuous neuroinflammation, which in the end can cause various pathologies. Innate immunity is the first line of defense against pathogens, and macrophages play a decisive role in immunosurveillance. Several innate immune molecules can contribute to neuron cytotoxicity. Despite the different etiologies, a common feature of neurodegenerative diseases is the chronic activation of innate immune cells within the CNS.

In this Special Issue on “Innate Immunity Paroxysm In Neurodegenerative Diseases”, we will cover recent research topics and current review articles in the field of neuroinflammation, brain innate immunity, neurodegeneration, neurocytokines/chemokines, and the role of immunosurveillance in the brain.

Prof. Dr. Michelino Di Rosa
Dr. Cristina Sanfilippo
Dr. Loretta Giuliano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • macrophage
  • microglia
  • lymphocyte
  • chitinases
  • Alzheimer’s disease
  • astrocyte
  • bioinformatics
  • Neuro HIV

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop