Special Issue "Infectious Ocular Disorders and Molecular Analysis"
Deadline for manuscript submissions: 31 October 2021.
Interests: ocular immunology; ocular infection; herpesvirus, uveitis, T cells; retinal degeneration; iPS cells; transplantation; immune rejection
Pathogen detection is important in the diagnosis and diagnosis-based treatment of infectious ocular disorders. However, it is difficult to detect pathogens because of the small amounts of samples obtained from the ocular region. Therefore, a method to detect such pathogens with high sensitivity/specifity and rapidity from a small amount of specimen is required for the diagnosis of ocular infections. In addition, the pathogens include bacteria, fungi, viruses, and parasites. Recently, polymerase chain reaction (PCR) diagnosis using local ocular specimens has become indispensable in the treatment of infectious uveitis, kerititis, and retinitis. Other molecular analyses such as genome sequence analysis, metagenome analysis, and so on have also been performed on those specimens in basic reseach.
Our reserch group developed the first PCR examination system in the ophthalmology field. We showed clinical applications of multiplex PCR (for the detection of, e.g., herpesvirus DNA) and broad-range PCR (for the detection of, e.g., bacteria 16S rDNA) to the specimens from eye infection. These advancements in PCR-based examination are still making a great contribution to our field. Our fellows also established a novel multiplex PCR, termed strip PCR prototype, for detecting 24 pathogens responsible for ocular infections. We further enhanced the technique by developing direct strip PCR that skips DNA extraction in the procedure. This PCR is anticipated to provide easier etiological evaluation even for general ophthalmologists, through the detection of more pathogens from ocular samples of infectious uveitis patients.
Therefore, this Special Issue of IJMS will focus on advances in the field of infectious ocular disorders by molecular analyses, including general PCR, real-time PCR, multiplex PCR, genome analysis, and so on. The target disorders are broad ocular infections such as keratitis, ocular surface infectious diseases (e.g., conjunctivitis), corneal endothelitis, uveitis, retinitis, and endophthalmitis. We are seeking novel research in the field of such molecular analyses on infectious ocular disorders. Our aim is for this Special Issue to shed light on multidisciplinary researchs that examine infection in the eye using new molecular analyses.
Dr. Sunao Sugita
Dr. Yoko Futatsugi
Manuscript Submission Information
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- ocular infections
- ocular surface infectious diseases
- corneal endotheliitis
- Polymerase chain reaction (PCR)
- genome analysis