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Special Issue "Inflammasome 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 September 2021.

Special Issue Editor

Prof. Kuo-Feng Hua
E-Mail Website
Guest Editor
1. Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan
2. Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Interests: NLRP3 inflammasome; inflammatory disease; renal disease; neurodegenerative diseases; cytokines; anti-inflammatory drug development; autophagy; drug repositioning
Special Issues and Collections in MDPI journals

Special Issue Information

Dear colleagues,

Inflammasomes are cytosolic caspase-1-containing protein complexes which recognize and respond to pathogen infection and diverse sterile host-derived or environmental danger signals to promote inflammatory disease development. Activation of inflammasomes leads to caspase-1-dependent maturation and release of proinflammatory cytokines IL-1β and IL-18 and promotes Gasdermin D-dependent pyroptotic cell death. Dysregulation of inflammasomes is associated with a number of inflammatory conditions, such as metabolic disorders, diabetes, cardiovascular diseases, neurodegenerative diseases, inflammatory bowel disease, kidney injury, and infectious diseases. As inflammasomes respond to a broad range of medically relevant stimuli, inflammasomes become a highly desirable drug target to treat a wide range of human diseases. Small molecule inhibitors targeting inflammasomes offer a new therapeutic strategy in new drug development. This Special Issue, “Inflammasome”, welcomes original research and review articles in the field, with a focus on but not limited to the molecular and mechanistic basis for inflammasome activation, inflammasome-associated pathogenesis, inflammasome inhibitor development, and inflammasome-specific therapeutics.

Prof. Kuo-Feng Hua
Guest Editor

Manuscript Submission Information

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Keywords

  • Inflammasome
  • Inflammatory disease
  • Caspase-1
  • Cytokines
  • Pyroptosis
  • NLRP3
  • Inflammasome inhibitor
  • Sterile inflammation

Published Papers (2 papers)

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Review

Open AccessReview
Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation
Int. J. Mol. Sci. 2021, 22(7), 3318; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073318 - 24 Mar 2021
Viewed by 379
Abstract
Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning has been changed by findings of its additional roles in diverse biological processes. Although caspase-8 [...] Read more.
Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning has been changed by findings of its additional roles in diverse biological processes. Although caspase-8 was not originally thought to be involved in the inflammation process, many recent works have determined that caspase-8 plays an important role in the regulatory functions of inflammatory processes. In this review, we describe the recent advances in knowledge regarding the manner in which caspase-8 modulates the inflammatory responses concerning inflammasome activation, cell death, and cytokine induction. Full article
(This article belongs to the Special Issue Inflammasome 2.0)
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Open AccessReview
Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
Int. J. Mol. Sci. 2021, 22(2), 872; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020872 - 16 Jan 2021
Viewed by 878
Abstract
The inflammasome is a three-component (sensor, adaptor, and effector) filamentous signaling platform that shields from multiple pathogenic infections by stimulating the proteolytical maturation of proinflammatory cytokines and pyroptotic cell death. The signaling process initiates with the detection of endogenous and/or external danger signals [...] Read more.
The inflammasome is a three-component (sensor, adaptor, and effector) filamentous signaling platform that shields from multiple pathogenic infections by stimulating the proteolytical maturation of proinflammatory cytokines and pyroptotic cell death. The signaling process initiates with the detection of endogenous and/or external danger signals by specific sensors, followed by the nucleation and polymerization from sensor to downstream adaptor and then to the effector, caspase-1. Aberrant activation of inflammasomes promotes autoinflammatory diseases, cancer, neurodegeneration, and cardiometabolic disorders. Therefore, an equitable level of regulation is required to maintain the equilibrium between inflammasome activation and inhibition. Recent advancement in the structural and mechanistic understanding of inflammasome assembly potentiates the emergence of novel therapeutics against inflammasome-regulated diseases. In this review, we have comprehensively discussed the recent and updated insights into the structure of inflammasome components, their activation, interaction, mechanism of regulation, and finally, the formation of densely packed filamentous inflammasome complex that exists as micron-sized punctum in the cells and mediates the immune responses. Full article
(This article belongs to the Special Issue Inflammasome 2.0)
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