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Special Issue "Inflammation versus Resolution: New Insights and Therapeutic Challenges in Atherosclerosis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Prof. Dr. Elena Monica Borroni
E-Mail Website
Guest Editor
1. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
2. Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy
Interests: immunology; immundeficiencies; tumors; chemokine receptors; signaling
Special Issues, Collections and Topics in MDPI journals
Dr. Benedetta Savino
E-Mail Website
Guest Editor
1. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
2. Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy
Interests: immunology; tumors; macrophages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Atherosclerosis is a leading cause of morbidity and mortality in the Western world. It is a lipid-driven inflammatory disease of the arterial intima in which the balance between pro-inflammatory and inflammation-resolving mechanisms dictates the final clinical outcome. In its pathogenesis, endothelial cell damage causes the accumulation of oxidized low-density lipoproteins and exposes proteoglycans, thus inducing the synthesis of chemotactic and adhesion molecules that promote the recruitment of inflammatory cells in the intima. Activated leukocytes stimulate a cascade of reactions that is normally counterbalanced by body defense mechanisms, resolving or stabilizing the lesion with the help of endogenous mediators—so-called SPMs (specialized pro-resolving mediators). Nevertheless, if the inflammatory response is not well tackled, an imbalance in the ratio between SPM and pro-inflammatory lipids leads to plaque progression and vulnerability to rupture and thrombosis.

This Special Issue is aimed to collect original research and review articles on genetic, molecular, and cellular mechanisms that are recognized as key players in inflammation and resolution, and which might represent valid targets of new therapeutic challenges for the treatment of atherosclerosis.

Prof. Dr. Elena Monica Borroni
Dr. Benedetta Savino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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