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Special Issue "Changes in Inhibitory Synapse Composition and Plasticity along the Progression of Neurodegenerative Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Eva Kiss
Guest Editor
Department of Cellular and Molecular Biology, University of Medicine, Pharmacy, Science and Technology “G.E. Palade” of Târgu Mures, Târgu Mureș, Romania
Interests: Alzheimer's disease; inhibitory synapses; gephyrin; neurodegeneration; neuorinflammation; microglia

Special Issue Information

Dear Colleagues,

The still incompletely understood pathogenesis of neurodegenerative diseases represents one important reason previous therapeutic approaches failed to effectively cure or delay their progression. Synaptic dysfunction, including altered synaptic plasticity, seems to be a central pathophysiological process in several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Research in recent years has strongly supported the involvement of GABAergic neurotransmission in both early and late pathogenesis of these groups of diseases. The GABAergic system might undergo dynamic remodeling and play different roles in the pathology at various disease stages. This seems to include stage-dependent alterations in presynaptic and postsynaptic components of inhibitory synapses and particularly scaffolding, anchoring and supporting proteins of GABAA receptors which influence the plasticity of the GABAergic system. The modulation of GABAergic neurotransmission through targeting inhibitory synapse proteins and their interactions (e.g., receptor–scaffold protein interactions) was proposed as a promising pharmacological strategy to normalize synapse dynamics and restore cognitive function.

This Special Issue of IJMS encourages primarily original research articles and short communications that expand present and identify new perspectives and molecular details for a more profound understanding of the GABAergic system along neurodegeneration. Review articles covering the most recent discoveries in this area and new therapeutic approaches targeting GABAergic synapses are also welcome.

Dr. Eva Kiss
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegeneration
  • inhibitory synapse
  • synaptic plasticity
  • scaffolding proteins
  • animal models
  • imaging

Published Papers

This special issue is now open for submission.
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