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Special Issue "The Interaction between Cell and Virus"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editor

Prof. Dr. Masahiro Fujimuro
E-Mail Website
Guest Editor
Department of Cell Biology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
Interests: Kaposi’s sarcoma-associated herpesvirus post-translational modification proteasome ubiquitin virus

Special Issue Information

Dear Colleagues,

Viral infections cause various diseases in the host species. Antiviral medications can help to relieve the symptoms of some viruses by inhibiting viral enzymes or virus-mediated events. However, during the past half century, very few antiviral drugs (excluding anti-HCV drugs) have been developed for use in the treatment of serious and life-threatening viral infections.

A fundamental step for the effective infection and replication of all viruses is the interaction between cell and virus. This is achieved through the dysregulation and exploitation of host cell functions (e.g., gene expression, signal transduction, metabolic process, intracellular transport, organelle biogenesis or communication, apoptosis, protein degradation, and immune response) by viral molecules, such as viral proteins and microRNA. Viruses hijack the appropriate cellular functions for establishment of infection, persistent infection, prolonging survival, control of cell proliferation, anti-apoptosis, and evasion of immune surveillance in infected cells. Viruses manipulate those cellular functions in order to create a favorable environment for the virus or the virus-infected cell. On the other hand, the host species exerts antiviral effects on virus infection through the interaction between cell and virus.

A better understanding of the interaction between viruses and host cells could provide new insights into the process of pathogenesis, immune disruption (or activation), and tumorigenesis triggered by viruses and may provide a theoretical basis for the development of novel therapeutic interventions against infectious diseases.

For this Special Issue, original research articles, review articles and short communications are welcome. Research areas of interest include the cell–virus interaction involved in viral replication, gene expression, latent or lytic infection, viral structural protein and enzyme, virus assembly, cell signaling pathway, post-translational modification, host factor, virus immune evasion, host immune response, viral tumorigenesis or disease, antiviral medication, vaccine, animal model, and gene therapy.

Prof. Dr. Masahiro Fujimuro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • viral replication
  • gene expression
  • lytic infection
  • viral structure
  • viral assembly
  • cell signaling pathway
  • post-translational modification
  • immune evasion
  • viral tumorigenesis
  • antiviral medication

Published Papers

This special issue is now open for submission.
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