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Special Issue "Intercellular Communication in Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Mustapha Kandouz
E-Mail Website
Guest Editor
Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Interests: Intercellular communication; Cancer; Ephrins; Connexins; Apoptosis; Autophagy; Intracellular trafficking; Receptor tyrosine kinases
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

It goes without saying that multicellular organisms are “social” entities, and that intercellular communication is a sine qua non condition for tissue homeostasis during organism development and for proper biological functioning of tissues. This means that cells are intricately interdependent at the deepest molecular levels. In addition to responding to signaling cues received from their acellular microenvironment, be it the extracellular matrix or fluidic streams, among others, they “listen” to other cells, whether via direct membrane-based cell–cell contacts or via factors released in the milieu. Intercellular communication is thus, understandably, key to comprehending all normal and pathological processes.

In this Special Issue of IJMS, I am pleased to invite manuscripts reporting data that focus on how molecular dysfunction in different types of intercellular communications, i.e., direct membrane-based interactions between cells (gap, tight, adherens, etc.), exosomes and other vesicular structures, tunneling nanotubes, Ephrins, Semaphorins, growth factors and receptors, etc., can contribute to cancer development, progression, and drug resistance, and how specific therapeutic strategies could be developed to take aim at these communication devices. Our aim is to reflect on the extent to which different communication processes result in distinct molecular wirings of cancer-prone, cancerous cells or drug-resistant cells. In particular, we believe that it is of great importance to compare direct membrane-based cell–cell contacts to released factor-based contactless communication.

Dr. Mustapha Kandouz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • intercellular communication
  • cell–cell communication
  • ephrins
  • connexins
  • growth factors
  • cancer
  • cancer therapy
  • cancer resistance
  • junctions
  • interaction

Published Papers

This special issue is now open for submission.
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