Special Issue "Role of Ion-Channels in Signal Transduction and Gene Regulation"
Deadline for manuscript submissions: 30 June 2021.
Interests: Ca2+ signaling; store-operated Ca2+ channels; Orai; STIM; MRS2; TRPV6; TRPV5; TRPC; optoelectronics
Interests: calcium signaling; CRAC; STIM; Orai; autophagy; transcription factor activation; MITF; TFEB
Signal transduction subsequent to ion flux across channels that are located in the plasma membrane and organelle membranes can regulate the expression of several genes. Extensive research is still required in order to understand how these signaling pathways are controlled in time and space, and which specific signaling proteins are involved. Therefore, we are organizing this Special Issue in order to resolve ion-dependent signaling pathways. The activity of several ion channels regulates various intracellular ion concentrations and activates either locally (microdomains) or globally specific signaling cascades. The most prominent second messenger ion is represented by calcium in excitable and non-excitable cells. This ion can lead to transcription factor activation followed by associated gene expression. However, other ions like Mg2+ and K+ also contribute to the regulation of transcription factor activation.
The aim of this Special Issue of the International Journal of Molecular Sciences is to further expand our current knowledge on the relationship between ion flux, signal transduction, and gene expression. We welcome reviews and original research articles that explore, but are not limited to, the structure and function of calcium signaling complexes and ion-dependent stimulation of gene regulation.
Dr. Rainer Schindl
Dr. Romana Schober
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- ion channels
- ion channel signaling complexes
- transcription factor
- transcriptional regulation
- gene expression