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Special Issue "Role of Ion-Channels in Signal Transduction and Gene Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Dr. Rainer Schindl
Guest Editor
Medical University of Graz, Gottfried Schatz Research Center, A-8010 Graz, Austria
Interests: Ca2+ signaling; store-operated Ca2+ channels; Orai; STIM; MRS2; TRPV6; TRPV5; TRPC; optoelectronics
Dr. Romana Schober
Guest Editor
Institute for Biophysics, Johannes Kepler University Linz, A-4040 Linz, Austria
Interests: calcium signaling; CRAC; STIM; Orai; autophagy; transcription factor activation; MITF; TFEB

Special Issue Information

Dear Colleagues,

Signal transduction subsequent to ion flux across channels that are located in the plasma membrane and organelle membranes can regulate the expression of several genes. Extensive research is still required in order to understand how these signaling pathways are controlled in time and space, and which specific signaling proteins are involved. Therefore, we are organizing this Special Issue in order to resolve ion-dependent signaling pathways. The activity of several ion channels regulates various intracellular ion concentrations and activates either locally (microdomains) or globally specific signaling cascades. The most prominent second messenger ion is represented by calcium in excitable and non-excitable cells. This ion can lead to transcription factor activation followed by associated gene expression. However, other ions like Mg2+ and K+ also contribute to the regulation of transcription factor activation.

The aim of this Special Issue of the International Journal of Molecular Sciences is to further expand our current knowledge on the relationship between ion flux, signal transduction, and gene expression. We welcome reviews and original research articles that explore, but are not limited to, the structure and function of calcium signaling complexes and ion-dependent stimulation of gene regulation.

Dr. Rainer Schindl
Dr. Romana Schober
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ion channels
  • ion channel signaling complexes
  • transcription factor
  • calcium
  • potassium
  • autophagy
  • transcriptional regulation
  • gene expression

Published Papers (1 paper)

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Open AccessArticle
Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl Channels Induced by Local Ca2+ Entry in HEK293
Int. J. Mol. Sci. 2021, 22(9), 4767; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094767 - 30 Apr 2021
Viewed by 218
Microdomains formed by proteins of endoplasmic reticulum and plasma membrane play a key role in store-operated Ca2+ entry (SOCE). Ca2+ release through inositol 1,4,5-trisphosphate receptor (IP3R) and subsequent Ca2+ store depletion activate STIM (stromal interaction molecules) proteins, sensors [...] Read more.
Microdomains formed by proteins of endoplasmic reticulum and plasma membrane play a key role in store-operated Ca2+ entry (SOCE). Ca2+ release through inositol 1,4,5-trisphosphate receptor (IP3R) and subsequent Ca2+ store depletion activate STIM (stromal interaction molecules) proteins, sensors of intraluminal Ca2+, which, in turn, open the Orai channels in plasma membrane. Downstream to this process could be activated TRPC (transient receptor potential-canonical) calcium permeable channels. Using single channel patch-clamp technique we found that a local Ca2+ entry through TRPC1 channels activated endogenous Ca2+-activated chloride channels (CaCCs) with properties similar to Anoctamin6 (TMEM16F). Our data suggest that their outward rectification is based on the dependence from membrane potential of both the channel conductance and the channel activity: (1) The conductance of active CaCCs highly depends on the transmembrane potential (from 3 pS at negative potentials till 60 pS at positive potentials); (2) their activity (NPo) is enhanced with increasing Ca2+ concentration and/or transmembrane potential, conversely lowering of intracellular Ca2+ concentration reduced the open state dwell time; (3) CaCC amplitude is only slightly increased by intracellular Ca2+ concentration. Experiments with Ca2+ buffering by EGTA or BAPTA suggest close local arrangement of functional CaCCs and TRPC1 channels. It is supposed that Ca2+-activated chloride channels are involved in Ca2+ entry microdomains. Full article
(This article belongs to the Special Issue Role of Ion-Channels in Signal Transduction and Gene Regulation)
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