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Special Issue "Acute Kidney Injury and Chronic Kidney Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Hajime Nagasu
E-Mail Website
Guest Editor
Department of Nephrology and Hypertension, Kawasaki Medical School, Kawasaki, Japan
Interests: Chronic Kidney Diseases; Inflammasome; ageing; macrophages; endothelial cells; mitochondria

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a progressive loss in kidney function over a period of months or years.  It has been known that CKD is not only the risk of kidney failure but also the risk of death. That is the reason why CKD is important health problem in world wide. Many factors, including diabetic status, hypertension, hypoxia and activation of renin-angiotensin system, were involved in the progression of renal disease, and its regulation is difficult. On the other hand acute kindey injury (AKI) is also global health problem. The global or local ischemia contributes to the pathogenesis of AKI. After tubular injury via ischemic stress, Excess inflammation has a pivotal role of progression of kidney injury. To resolve this problem, we have to address on the common pathway to progression of kidney diseases.

Chronic inflammation is one of the most important common pathways to progression of CKD and AKI. Inflammation has been implicated in the pathogenesis of CKD, resulting in disruption of the renal microvasculature, progressive damage to the glomerular capillaries, podocyte and endothelial cell apoptosis, and tubulointerstitial fibrosis. Inflammation also has pivotal role of the AKI to CKD continuum. These facts suggested that we should know about inflammation and innate immune system in all of the kidney diseases.

The topics of special issue address on the inflammation and innate immune system in kidney diseases including AKI and CKD.

Dr. Hajime Nagasu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic kidney diseases
  • acute kidney injury
  • inflammation
  • inflammaging
  • nephritis
  • innate immune system
  • macrophages
  • neutrophils

Published Papers

This special issue is now open for submission.
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