Special Issue "Acute Kidney Injury and Chronic Kidney Diseases"
Deadline for manuscript submissions: 31 August 2021.
Chronic kidney disease (CKD) is a progressive loss in kidney function over a period of months or years. It has been known that CKD is not only the risk of kidney failure but also the risk of death. That is the reason why CKD is important health problem in world wide. Many factors, including diabetic status, hypertension, hypoxia and activation of renin-angiotensin system, were involved in the progression of renal disease, and its regulation is difficult. On the other hand acute kindey injury (AKI) is also global health problem. The global or local ischemia contributes to the pathogenesis of AKI. After tubular injury via ischemic stress, Excess inflammation has a pivotal role of progression of kidney injury. To resolve this problem, we have to address on the common pathway to progression of kidney diseases.
Chronic inflammation is one of the most important common pathways to progression of CKD and AKI. Inflammation has been implicated in the pathogenesis of CKD, resulting in disruption of the renal microvasculature, progressive damage to the glomerular capillaries, podocyte and endothelial cell apoptosis, and tubulointerstitial fibrosis. Inflammation also has pivotal role of the AKI to CKD continuum. These facts suggested that we should know about inflammation and innate immune system in all of the kidney diseases.
The topics of special issue address on the inflammation and innate immune system in kidney diseases including AKI and CKD.
Dr. Hajime Nagasu
Manuscript Submission Information
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- chronic kidney diseases
- acute kidney injury
- innate immune system