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Special Issue "Kynurenine Pathway: A Bridge between Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Astrid Parenti
E-Mail Website
Guest Editor
Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Interests: inflammation and immunity in cardiovascular disease and cancer; vascular remodeling; cancer biology; diabetes
Dr. Eid Ali Hussein
E-Mail Website
Guest Editor
1. Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar
2. Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, 2713 Doha, Qatar
Interests: molecular pharmacology; Epac signaling; vascular alpha 2 adrenergic receptors

Special Issue Information

Dear Colleagues,

The kynurenine pathway (KP) is the major route for tryptophan catabolism. The first and limiting step in KP is primarily controlled by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO), which produce a range of biologically active metabolites, including kynurenine itself, kynurenic acid and nicotinamide adenine dinucleotide (NAD+). The products of KP are involved, directly or indirectly, in a wide range of mechanisms of the endocrine, haemopoietic, immune, cardiovascular (CV) and nervous system. Tryptophan is indeed essential for protein synthesis, and it is also converted into key neurotransmitters’ serotonin and tryptamine. Increased KP has been associated with several CV diseases, and, recently, significant interest has been focused on KP-induced immune escape, as demonstrated by pharmacological inhibition of IDO1 and TDO for cancer therapy.

In this Special Issue, we seek papers that present the latest evidence on KP research and discuss interplay between KP deregulation and human health and disease.

Dr. Astrid Parenti
Dr. Eid Ali Hussein
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • cardiovascular disease
  • immune escape
  • inflammation
  • brain disorders
  • neurodegeneration
  • aging
  • oxidative stress
  • indoleamine 2,3-dioxygenase
  • tryptophan 2,3-dioxygenase

Published Papers (1 paper)

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The Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies
Int. J. Mol. Sci. 2021, 22(18), 9879; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189879 - 13 Sep 2021
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The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes immunosuppression in response to infection or inflammation. Indoleamine 2,3-dioxygenase 1 (IDO1), the main enzyme of KP, has a broad spectrum of activity on immune cells regulation, controlling the balance [...] Read more.
The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes immunosuppression in response to infection or inflammation. Indoleamine 2,3-dioxygenase 1 (IDO1), the main enzyme of KP, has a broad spectrum of activity on immune cells regulation, controlling the balance between stimulation and suppression of the immune system at sites of local inflammation, relevant to a wide range of autoimmune and inflammatory diseases. Various autoimmune diseases, among them endocrinopathies, have been identified to date, but despite significant progress in their diagnosis and treatment, they are still associated with significant complications, morbidity, and mortality. The precise cellular and molecular mechanisms leading to the onset and development of autoimmune disease remain poorly clarified so far. In breaking of tolerance, the cells of the innate immunity provide a decisive microenvironment that regulates immune cells’ differentiation, leading to activation of adaptive immunity. The current review provided a comprehensive presentation of the known role of IDO1 and KP activation in the regulation of the innate and adaptive arms of the immune system. Significant attention has been paid to the immunoregulatory role of IDO1 in the most prevalent, organ-specific autoimmune endocrinopathies—type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis. Full article
(This article belongs to the Special Issue Kynurenine Pathway: A Bridge between Health and Disease)
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