Special Issue "Kynurenine Pathway: A Bridge between Health and Disease"
Deadline for manuscript submissions: 31 December 2021.
Interests: inflammation and immunity in cardiovascular disease and cancer; vascular remodeling; cancer biology; diabetes
2. Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, 2713 Doha, Qatar
Interests: molecular pharmacology; Epac signaling; vascular alpha 2 adrenergic receptors
The kynurenine pathway (KP) is the major route for tryptophan catabolism. The first and limiting step in KP is primarily controlled by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO), which produce a range of biologically active metabolites, including kynurenine itself, kynurenic acid and nicotinamide adenine dinucleotide (NAD+). The products of KP are involved, directly or indirectly, in a wide range of mechanisms of the endocrine, haemopoietic, immune, cardiovascular (CV) and nervous system. Tryptophan is indeed essential for protein synthesis, and it is also converted into key neurotransmitters’ serotonin and tryptamine. Increased KP has been associated with several CV diseases, and, recently, significant interest has been focused on KP-induced immune escape, as demonstrated by pharmacological inhibition of IDO1 and TDO for cancer therapy.
In this Special Issue, we seek papers that present the latest evidence on KP research and discuss interplay between KP deregulation and human health and disease.
Dr. Astrid Parenti
Dr. Eid Ali Hussein
Manuscript Submission Information
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- cardiovascular disease
- immune escape
- brain disorders
- oxidative stress
- indoleamine 2,3-dioxygenase
- tryptophan 2,3-dioxygenase