Special Issue "Recent Advances of Leukemia Pathophysiology: From Molecular Basis to Targeted Therapies"
Deadline for manuscript submissions: 30 November 2021.
Interests: myeloid leukemia; therapy resistance; microenvironment; hypoxia; mRNA translation; RNA-binding proteins
This Special Issue will focus on molecular mechanisms supporting leukemia development, which could be used as targets for precision medicine.
The occurrence of an oncogene is a factor driving malignant transformation, which is followed by deep molecular changes. Variation in gene expression regulation has an impact on the course of cellular processes. Leukemia development is related to the progressive dysregulation of cell signaling due to the affected level of proteins playing a regulatory role in cellular pathways. The basis of this alteration is mostly a malfunction of factors controlling gene expression at the stage of transcription (e.g., DNA methylation, transcription factors) or post-transcriptionally (e.g., splicing, mRNA modification and turnover) through translation process (e.g., mRNA translation initiation or ribosome heterogeneity). Recent advances demonstrate that these factors contribute to cancer progression by an indirect influence on cellular processes essential for cancer cells’ propagation and survival of chemotherapy, such as cell quiescence/proliferation, differentiation, or apoptosis. Moreover, improper control of cell-cycle progression as well as DNA damage signaling and repair enhance genomic instability, pushing forward the progression of leukemia.
The aim of this Special Issue is to highlight recently discovered molecular constituents emerging as potential therapeutic targets, which contribute to leukemia progression and chemo-resistance by affecting cellular signaling, gene expression, post-transcriptional regulation, or protein translation processes. Original papers and reviews are invited for submission.
Dr. Paulina Podszywałow-Bartnicka
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- regulation of gene expression
- post-transcriptional regulation
- protein synthesis
- cell cycle
- DNA damage and repair
- precision medicine
- therapy resistance