Special Issue "Lipid Emulsion in Toxicology"
Deadline for manuscript submissions: 31 October 2021.
Interests: anesthetics; vascular pharmacology; lipid emulsion; local anesthetic toxicity; calcium; nitric oxide; smooth muscle contraction
Lipid emulsion was initially developed for parenteral nutrition. Lipid emulsion has been widely used for the treatment of local anesthetic systemic toxicity. In addition, these days, lipid emulsion was reported to be effective in alleviating toxicity of nonlocal anesthetic drugs with high lipid solubility. Although lipid emulsion is used to treat intractable cardiovascular collapse induced by toxicity of nonlocal anesthetic drugs (amitriptyline, bupropion, quetiapine, verapamil, and diphenhydramine) with high lipid solubility, many physicians have a tendency to consider only the lipid sink as the underlying mechanism, in which the lipid emulsion absorbs highly lipid soluble drugs from vital organs, leading to a reduction in the offending drug content in vital organs such as the heart. However, many mechanisms other than the lipid sink have been demonstrated to be involved experimentally, including lipid shuttle (enhanced redistribution), inotropic effects, inhibition of nitric oxide production, fatty acid supply, attenuation of mitochondrial dysfunction, and glycogen synthase kinase-3b phosphorylation. For this Special Issue, we welcome all research papers associated with lipid emulsion treatment of systemic toxicity induced by local anesthetics or nonlocal anesthetic drugs, including antidepressants, antipsychotics, calcium channel blockers, and anti-arrhythmic. Such a collection would be helpful in providing insights toward improving lipid emulsion treatment of toxicity caused by local anesthetic or nonlocal anesthetic drugs.
Dr. Ju-Tae Sohn
Manuscript Submission Information
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- lipid emulsion
- local anesthetic toxicity
- nonlocal anesthetic drug toxicity
- cardiac arrest
- cardiac arrhythmia