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Special Issue "Molecular Research in Allergic Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 November 2020).

Special Issue Editors

Prof. Dr. Fiorentina Roviezzo
E-Mail Website
Guest Editor
Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy
Interests: pulmonary inflammation, sphingolipid, airway inflammation
Special Issues and Collections in MDPI journals
Dr. Antonietta Rossi
E-Mail Website
Guest Editor
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy
Interests: eicosanoids; sex; asthma; 5-lipoxygenase

Special Issue Information

Dear colleagues,

Over the last years bioactive lipids have emerged as clinically-relevant mediators of allergic disease pathophysiology. Compelling evidence suggests the importance of lipid mediators in the development of asthma, allergic rhinitis, atopic dermatitis, anaphylaxis, and food allergy. Lipids play key roles in cell signaling events, influencing physiologic (bronchial tone) and immune mechanisms (degranulation, chemotaxis, and sensitization) in allergic diseases. Lipids act through several cellular mechanisms such as the formation of structural support platforms (lipid rafts) for receptor signaling complexes, the activation of a diverse family of G-protein coupled receptors, and the mediation of intracellular signaling cascades by acting as second messengers. An increased understanding of these critical bioactive molecules will drive future innovations in treating atopy in its many forms. This Special Issue aims to shed light on and further the understanding of some of these intricate signaling mechanisms in allergic diseases. Specifically, we propose to explore and discuss the following points: (1) lipid synthesis pathways and signaling in atopic disease pathology; (2) the development of allergic disease treatments targeting lipid mediator pathways

Prof. Fiorentina Roviezzo
Dr. Antonietta Rossi
Guest Editors

Manuscript Submission Information

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Keywords

  • atopy
  • asthma
  • immune inflammation
  • sphingolipid
  • leukotrienes
  • anaphylaxis
  • therapeutic targets
  • food allergy

Published Papers (2 papers)

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Review

Review
The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
Int. J. Mol. Sci. 2020, 21(5), 1851; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051851 - 08 Mar 2020
Cited by 11 | Viewed by 1513
Abstract
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled [...] Read more.
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease. Full article
(This article belongs to the Special Issue Molecular Research in Allergic Diseases)
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Review
The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
Int. J. Mol. Sci. 2019, 20(14), 3580; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20143580 - 22 Jul 2019
Cited by 33 | Viewed by 2498
Abstract
Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various [...] Read more.
Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications. Full article
(This article belongs to the Special Issue Molecular Research in Allergic Diseases)
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