Special Issue "Lipid Metabolism in Cancer as a Source of Biomarkers and Therapeutical Targets"
Deadline for manuscript submissions: 30 November 2021.
Interests: membrane lipidome; imaging mass spectrometry; inflammatory bowel disease; colorectal cancer; lipid fingerprint; lipid biomarkers; lipid pharmacological targets
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Special Issue in International Journal of Molecular Sciences: New Insights in Immune Cell Diversity: A Bridge Between the Patient Stratification and Personalized Therapies
Recent advances in lipidomic and metabolomic techniques have placed lipids in a crucial spot in the field of biomedicine.
On the one hand, it is well known that malignant cells reshape their biosynthetic and bioenergetic requirements to be able to cope with the specific demands associated with the formation and maintenance of the cancer process. In addition to providing energy, the enhancement of lipid uptake and the sustained activation of the de novo lipogenesis make cancer cells the membrane building blocks needed to support rapid proliferation, as well as a repertoire of lipid signaling molecules.
On the other hand, the development of imaging mass spectrometry techniques has helped to demonstrate beyond doubt that the cell lipid profile is cell type-dependent. Even more, cell lipidome has turned out to be highly sensitive to pathophysiological alterations, such as differentiation or tumorigenesis.
However, the regulatory mechanisms that finely control the levels and fate of each one of the lipid species detected remain largely unknown, which make it complicated to infer the biological impact of the results. In this context, the combination of “-omic” techniques, particularly using system biology approaches, could provide new hints to understand the complex networks underlying the control of lipid metabolism. Altogether, the study of lipid metabolism offers a unique opportunity to identify new therapeutic targets and novel specific biomarkers for cancer.
This Special Issue aims to highlight the research and strategies currently used to identify lipid biomarkers for cancer diagnosis, prognosis and treatment monitoring. It also welcomes all those studies seeking to elucidate new regulatory pathways of the lipidome and their role in tumorigenesis and cancer progression by combining different “omic” techniques.
Dr. Gwendolyn Barceló-Coblijn
Dr. Alice Chaplin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- membrane lipid metabolism
- system biology
- imaging mass spectrometry
- stem cells
- cancer risk factors
- lipid biomarkers
- lipid pharmacological targets