Dear Colleagues,

Lipids are a heterogeneous class of biomolecules which altered metabolism is one of the key features of cancer, relevant for development, chemotherapy and immunotherapy. Indeed, lipids modulate cell signaling through the lipid–protein and lipid–lipid interactions and membrane dynamics; increasing lipid content promotes cell proliferation, tumor progression, and chemotherapy resistance and fatty acids are needed for energy storage, membrane structure, and precursors of signaling molecules. Most of the enzymes and carriers involved in lipid procurement and synthesis are abnormally expressed in cancer cells and in some conditions their chemical and genetic inhibition effects cancer viability and immune response. Therefore, this Special Issue will describe recent advances in the understanding of the role of lipids and their metabolites on cancer progression and therapy success. For this aim, we will present studies that highlight the impact of peculiar lipid phenotype on cancer progression and immune cell phenotyping. In addition, this Special Issue could be an opportunity to present new molecular and/or cellular mechanisms of action of lipids and to propose new targets to ameliorate the anticancer strategies.

Dr. Angela Maria Rizzo
Dr. Paola Antonia Corsetto
Guest Editors

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• lipid
• lipid metabolism
• tumor progression
• immunotherapy
• lipid–protein interactions
• fatty acids