Special Issue "MAPK-ERK Pathway"
Deadline for manuscript submissions: closed (31 January 2021).
Interests: Mechanisms of MEK/ERK growth arrest signaling
The Raf/MEK/Extracellular signal-regulated kinase (ERK/MAPK) pathway is a highly specific three-layered kinase cascade that has pivotal roles in a variety of cellular processes, including cell cycle progression, survival, and differentiation. The deregulation of this pathway is implicated in a variety of pathophysiological conditions, including cancers, metabolic diseases, neurological disorders, and genetically inherited disorders. The kinase cascade of this pathway consists of the Ser/Thr kinases, A-Raf, B-Raf, and C-Raf-1, the highly homologous dual-specificity kinases, MEK1 and MEK2, and the ubiquitously expressed serine/threonine kinase, ERK1 and ERK2 (collectively referred to as ERK1/2). As the key focal point of pathway signaling, ERK1/2 activate/inactivate a variety of targets, including transcription factors, other kinases, phosphatases, cytoskeletal proteins, scaffolds, receptors, and signaling components. The specificity of pathway signaling is determined at multiple levels, including regulation of the magnitude and duration of pathway activity, spatio-temporal regulation, regulation of the monomeric vs. dimeric status of ERK1/2, as well as its crosstalk with other pathways. Recent studies have substantially expanded our knowledge of the pathway signaling at molecular levels, allowing the development of diverse potential therapeutic strategies targeting this pathway.
This Special Issue covers recent advances in the molecular mechanisms and biological functions of the ERK/MAPK pathway signaling, its regulators and downstream effectors, as well as the relevance of these aspects in human disease and potential therapeutic strategies. We encourage authors to submit original research articles or reviews.
Prof. Dr. Jong-In Park
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ERK/MAPK signaling in cell survival, proliferation, and differentiation
- aberrant ERK/MAPK signaling in disease
- regulators of the ERK/MAPK pathway
- downstream effectors of the ERK/MAPK pathway
- targeting the ERK/MAPK pathway in diseases
- drug resistance to the ERK/MAPK pathway inhibition