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Special Issue "MicroRNA as Biomarkers in Cancer Diagnostics and Therapeutics (III)"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editor

Dr. Lorenzo F. Sempere
E-Mail Website1 Website2
Guest Editor
Department of Radiology, Precision Health Program, Michigan State University, East Lansing, MI 48824, USA
Interests: tissue slide-based microRNA diagnostics; microRNA biology and evolution; cell type-specific activities of microRNAs in cancer; breast cancer; pancreatic cancer
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) are small non-coding RNA molecules that function predominantly as post-transcriptional regulators of gene expression. miRNAs play important roles in development, cellular differentiation and homeostasis, and host–virus interactions. miRNA expression and function are dysregulated in cancer. Specific miRNAs have been shown to exert tumor-promoting or tumor-suppressive functions depending of the expressing cell type and cancer site. Within cancer cells, miRNA can modulate growth and chemoresistance, stem cell, epithelial-to-mesenchymal transition and/or metastatic programs. Within other cell types of the tumor microenvironment, miRNAs can promote angiogenic and immune suppressive programs.

Most miRNAs act in a cell-autonomous fashion within the expressing cell, yet miRNAs are an important cargo in extracellular vesicles that can affect specific biological programs or pathways in recipient cells. There are several examples of miRNA-mediated cell-to-cell communication that impart a favorable microenvironment for cancer cell growth and metastasis. Circulating miRNAs either in extracellular vesicles, multi-protein complexes, or in other forms are readily found and often altered in the blood and other bio-fluids of cancer patients.

This Special Issue will provide a comprehensive update on the latest findings on cancer-associated miRNAs, with a focus on the clinical application of miRNAs as biomarkers for cancer diagnosis and prognosis, and treatment prediction, as well as miRNA-based therapeutic strategies.

Original papers and review articles that describe advances in detection methodology, bioinformatics approaches, and statistical analysis with an impact on the clinical application of miRNAs as cancer biomarkers are welcome.

Dr. Lorenzo F. Sempere
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • microRNA (miRNA, miR)
  • tissue analysis
  • circulating biomarkers (blood, bio-fluids)
  • extracellular vesicle, exosomes
  • cancer diagnosis
  • treatment prediction
  • therapeutics

Published Papers

This special issue is now open for submission.
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