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Special Issue "Major Histocompatibility Complex (MHC) Regulation of Autoantibody Responses"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 June 2022.

Special Issue Editor

Dr. Kenneth Michael Pollard
E-Mail Website
Guest Editor
Department of Molecular Medicine, IMM208, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Interests: autoimmunity; genetics; inflammation; animal models; xenobiotics

Special Issue Information

Dear Colleagues,

This Special Issue of the International Journal of Molecular Sciences will focus on the importance of major histocompatibility complex (MHC) restriction in autoantibody responses. MHC restriction describes the ability of the T cell receptor (TCR) to recognize antigenic peptides presented by the MHC. This interaction dictates both the specificity and long-lasting memory of cellular and/or humoral immune responses. Although MHC restriction plays an essential role in protective immunity, it can underlie autoimmunity as evidenced by the fact that MHC loci constitute significant risk factors for autoimmune diseases. The goal of this Special Issue is to highlight mechanisms by which interaction of self-peptides (autoantigens) with MHC leads to specific autoantibody responses, particularly those that may have diagnostic potential for human-organ-specific and systemic autoimmune diseases. One mechanism known to be important in MHC-restricted responses is post-translational modifications of self-antigens. Other mechanisms thought to contribute include protein/peptide misfolding, proteolysis, structural perturbation of MHC, and atypical docking of TCRs to peptide–MHC complexes. To provide a resource of current thinking in this field, we seek insightful research articles or timely reviews focused on how the interaction of MHC with self-antigens leads to T and B cell responses culminating in autoantibody responses, particularly those of diagnostic or pathologic significance. Contributions describing studies in human and/or animal models are welcome.

Dr. Kenneth Michael Pollard
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aberrant TCR reactivity
  • antigen presentation
  • animal model
  • atypical TCR–MHC docking
  • autoantibody
  • autoimmunity
  • autoimmune disease
  • extracellular proteases
  • human
  • MHC restriction
  • perturbation of MHC structure
  • post-translational modification
  • protein misfolding

Published Papers

This special issue is now open for submission.
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