Special Issue "Applications of Mesenchymal Stem Cells in Neuroscience"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: Mesenchymal stem cells; extracellular vesicles; microvesicles; exosomes, Alzheimer’s disease; microglial cells; inflammation
Interests: Neuroimmunological disorders; mesenchymal stem cells; extracellular vesicles; Alzheimer's disease; diabetes; stroke; inflammation; aptamers
Multipotent Mesenchymal Stem Cells (MSC) have recently become very popular in cell therapy applications due to their multifaceted properties. Initially exploited for non-neurological pathologies, they are now also being applied in neurosciences. It has emerged, in fact, that most neurological conditions would benefit from a treatment able to provide tissue repair (neuro-protection and neuro-restoration) and immunomodulatory effects (immunosuppressive and anti-inflammatory actions) delivered exactly at the site where it is needed. Therefore, new strategies are being studied to target inflammation and possibly to promote the intrinsic regeneration potential. Along these directions, MSC are emerging as an extremely attractive tool due to their ability to release a proactive secretome composed of soluble factors and/or extracellular vesicles. MSC offer practical advantages for clinical applications because they can be isolated from adults with minimally invasive procedures. Applications of MSC or their by-products are now studied for the treatment of many neurological disorders, including neurodegenerative and traumatic conditions for which there is no ideal cure to date.
The purpose of this Special Issue is to provide an overview of the current status of MSC application in neurological conditions and to delineate the current foundations for possible future applications in this field.
Dr. Coco Silvia
Dr. Malosio Maria Luisa
Manuscript Submission Information
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- Mesenchymal stem cells
- extracellular vesicles
- exosomes, neurodegenerative diseases
- neurological conditions
- cell therapy