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Special Issue "Matricellular Proteins: Modifiers of Cell Behavior in Development, Disease & Tissue Remodeling"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 25 June 2021.

Special Issue Editors

Assoc. Prof. Douglas Hamilton
E-Mail Website
Guest Editor
Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St, London, ON N6A 5C1, Canada
Interests: non-healing skin wounds; the adhesion, migration, proliferation and differentiation of immune cells
Prof. Dr. Kim S. Midwood
E-Mail Website
Guest Editor
The university of Oxford
Prof. Dr. Kurt D. Hankenson
E-Mail Website
Guest Editor
University of Michigan Medical School, Department of Orthopaedic Surgery, Ann Arbor, United States
Dr. Olga Stenina Adognravi
E-Mail
Guest Editor
Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA

Special Issue Information

Dear Colleagues,

Matricellular proteins were first described by the Bornstein group in 1995. Since then, they have become a major focus of research in the area of extracellular matrix and cell biology. As a class of matrix proteins, matricellular proteins are characterized by their ability to modify the cell phenotype in health and disease and have been implicated in numerous cancer types, acute healing, and fibrosis. Matricellular proteins are important during development, but are typically restricted to tissue remodeling, wound repair, and remodeling in the normal adult. Matricellular proteins interact with cell surface receptors, such as integrins, and are able to bind growth factors as well as the structural components of the matrix, such as collagen. Galectins, tenascins, thrombospondins, SPARC, osteopontin, hevin, periostin, and bone sialoprotein are all classed as matricellular proteins, each with varying functions. Gene-deletion technology has shown that matricellular proteins have very specific functions, and few compensatory effects are evident. Indeed, the deletion of most matricellular proteins only becomes apparent after wounding of tissues in mice. Therefore, it appears that matricellular proteins are essential to the tissue response to pathological insults.

Assoc. Prof. Douglas Hamilton
Guest Editor

Manuscript Submission Information

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Published Papers (2 papers)

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Research

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Open AccessArticle
Periostin Is Required for the Maintenance of Muscle Fibers during Muscle Regeneration
Int. J. Mol. Sci. 2021, 22(7), 3627; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073627 - 31 Mar 2021
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Abstract
Skeletal muscle regeneration is a well-organized process that requires remodeling of the extracellular matrix (ECM). In this study, we revealed the protective role of periostin, a matricellular protein that binds to several ECM proteins during muscle regeneration. In intact muscle, periostin was localized [...] Read more.
Skeletal muscle regeneration is a well-organized process that requires remodeling of the extracellular matrix (ECM). In this study, we revealed the protective role of periostin, a matricellular protein that binds to several ECM proteins during muscle regeneration. In intact muscle, periostin was localized at the neuromuscular junction, muscle spindle, and myotendinous junction, which are connection sites between muscle fibers and nerves or tendons. During muscle regeneration, periostin exhibited robustly increased expression and localization at the interstitial space. Periostin-null mice showed decreased muscle weight due to the loss of muscle fibers during repeated muscle regeneration. Cultured muscle progenitor cells from periostin-null mice showed no deficiencies in their proliferation, differentiation, and the expression of Pax7, MyoD, and myogenin, suggesting that the loss of muscle fibers in periostin-null mice was not due to the impaired function of muscle stem/progenitor cells. Periostin-null mice displayed a decreased number of CD31-positive blood vessels during muscle regeneration, suggesting that the decreased nutritional supply from blood vessels was the cause of muscle fiber loss in periostin-null mice. These results highlight the novel role of periostin in maintaining muscle mass during muscle regeneration. Full article
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Review

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Open AccessReview
Functions of Thrombospondin-1 in the Tumor Microenvironment
Int. J. Mol. Sci. 2021, 22(9), 4570; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094570 - 27 Apr 2021
Viewed by 266
Abstract
The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated with progression in several cancers, while expression by nonmalignant cells in [...] Read more.
The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated with progression in several cancers, while expression by nonmalignant cells in the tumor microenvironment and circulating levels in cancer patients can be elevated. THBS1 is not a tumor suppressor gene, but the regulation of its expression in malignant cells by oncogenes and tumor suppressor genes mediates some of their effects on carcinogenesis, tumor progression, and metastasis. In addition to regulating angiogenesis and perfusion of the tumor vasculature, thrombospondin-1 limits antitumor immunity by CD47-dependent regulation of innate and adaptive immune cells. Conversely, thrombospondin-1 is a component of particles released by immune cells that mediate tumor cell killing. Thrombospondin-1 differentially regulates the sensitivity of malignant and nonmalignant cells to genotoxic stress caused by radiotherapy and chemotherapy. The diverse activities of thrombospondin-1 to regulate autophagy, senescence, stem cell maintenance, extracellular vesicle function, and metabolic responses to ischemic and genotoxic stress are mediated by several cell surface receptors and by regulating the functions of several secreted proteins. This review highlights progress in understanding thrombospondin-1 functions in cancer and the challenges that remain in harnessing its therapeutic potential. Full article
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