Special Issue "Molecular Mechanism Underlying the Endocrine Abnormalities Associated with Severe Illness"
Deadline for manuscript submissions: closed (31 August 2021).
Director, Division of Endocrinology, Diabetes and Metabolism Prisma Health Midlands, Columbia, SC, USA
The organism homeostasis and the endocrine system functions are closely related to each other. Although both are profoundly affected during a severe illness, a direct pathogenic role of changes in the endocrine system on the homeostasis of organisms during disease has not been established. The endocrine alterations observed during severe illness are considered adaptative. With the exception of glucocorticoids and insulin replacement, the prevalent idea in the clinical practice is that patients with hormonal abnormalities resulting from severe illness should not be given a hormonal replacement. Due to the very high prevalence of endocrine abnormalities resulting from diseases, this clinical attitude implies that the most common endocrine problems occurring in the inpatient setting are neglected.
Nowadays, patients can be maintained on artificial life support for a prolonged period of time. Consequently, the hormonal abnormalities associated with the disease can be several weeks or even months. As such, the consequences of nonintervention with a hormonal replacement should be revisited and reviewed.
We will address the molecular changes and mechanisms underlying the multiple endocrine abnormalities observed in patients with severe illness in this Special Issue. We will review the mechanisms responsible for the differences in serum hormonal levels, in the action of hormones at cellular levels, and in the endocrine glands’ morphology during illnesses. We hope that an accurate exposition of the knowledge acquired until today will lay the foundations for a rational scientific discussion about the current clinical practice regarding the endocrine system's function during illness.
Prof. Jose Joaquin Lado-Abeal
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