Dear Colleagues,

The rapid development of civilization has resulted in an increased risk of developing lifestyle diseases in societies. Additionally, most societies of well-developed countries are aging. These and other problems have resulted in a greater appreciation for the role of physical activity regarding health, at practically every stage of an individual’s development. The positive impact of well-chosen physical exercise in the prevention or slowing down of the development of lifestyle diseases is indisputable. However, the need to study the effect of exercise on the body is still high. Increased and improved techniques and research methods, the development of biological sciences, and the detection of new myokines mean that the full picture is far from complete. Moreover, new forms of training are being proposed that allow us to limit the time and maximize the effects of physical work. The body's response to exercise depends on many factors, including (apart from age, gender, etc.) the type of muscle contraction, type of exercise, the individual predispositions of the exerciser, and others. Therefore, selection of the optimal form of physical activity is still a challenge, which can be solved by detailed biochemical and molecular determinations. In particular, we are still far from explaining the impact of physical activity on a cellular level, both molecular and biochemical, as well as its effect on signalling pathways. All of this means that there is a great need for research, where the physiological changes induced by exercise can be explained by the molecular changes in a specific tissue or cell.

Prof. Dr. Jedrzej Antosiewicz
Guest Editor

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• exercise metabolomics
• exercise-induced gene expression
• exercise triggered cell signalling
• myokines
• iron metabolism
• exercise-induced oxidative stress