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Special Issue "Melatonin and Mitochondria"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Prof. Dr. Germaine Escames
E-Mail Website
Guest Editor
Health Sciences Technology Park, Universidad de Granada, Granada, Spain
Interests: melatonin; cancer; mucositis; mitochondria; oxidative stress; clock genes
Prof. Dr. Darío Acuña-Castroviejo
E-Mail Website
Guest Editor
Professor Dario Acuna-Castroviejo Melatonin, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain
Interests: melatonin; mitochondria; aging; neurodegeneration; sepsis; oxidative stress
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Given that mitochondria are well known to be the principal target of melatonin, there is increasing evidence for (i) the existence of a direct relationship between oxidative stress in mitochondria and melatonin antioxidant activity that protects them; (ii) the presence and synthesis of melatonin in these organelles; (iii) the existence of circadian/seasonal variations in mitochondrial structure and function, suggesting that melatonin may play a physiological role in the modus operandi of mitochondria; (iv) the major role of mitochondrial impairment in aging and multiple diseases including inflammatory, neurodegenerative and cancer ones. Melatonin directly affects the physiological regulation and energy metabolism of mitochondria, providing a novel homeostatic mechanism for regulating cell bioenergetics. Of note, a role of melatonin in protecting against COVID-19 infection has been proposed, and mitochondrial involvement in SARS-CoV-2 infection has been stated. The actions, molecular pathways, and doses of melatonin involved in these effects require further research.

This Special Issue is devoted to the impact of melatonin in mitochondria, with the idea of deepening knowledge of the basic molecular pathways. Therefore, we encourage all researchers working on this topic to submit their work mainly in the form of original contributions, although review manuscripts will also be welcome.

Prof. Dr. Germaine Escames
Prof. Dr. Darío Acuña-Castroviejo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Melatonin
  • Mitochondria
  • Aging
  • Cancer
  • Sepsis
  • Parkinson’s
  • Alzheimer’s
  • SARS-CoV-2

Published Papers

This special issue is now open for submission.
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