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Special Issue "Melatonin and Vitamin D: Molecular Mechanisms and Biological Function"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Konrad Kleszczyński
E-Mail Website
Guest Editor
Department of Dermatology, University of Münster, 48149 Münster, Germany
Interests: skin; biology of melanoma; melanogenesis; photobiology; dermatopathology; cutaneous cells; mitochondria; oxidative stress; melatonin and its metabolites
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrzej Slominski
E-Mail Website
Guest Editor
1. Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2. Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, AL 35294, USA
Interests: dermatopathology; skin pigmentation; neuroendocrinology of the skin; photobiology; melanoma; steroidogenesis; vitamin D; sterols; melatonin; stress response mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, numerous studies have provided new insights into the new biological capacities and health-related or clinical applications for melatonin, vitamin D as well as its metabolites. Namely, both substances have been widely documented as differentiative ones with beneficial impact such as the biological regulation of circadian rhythms, sleep, mood, reproduction, tumor growth, immune response, and neurodegenerative processes for melatonin or being a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, phosphate, and many other biological effects for vitamin D.

The Special Issue on “Melatonin and Vitamin D: Molecular Mechanisms and Biological Function” will include manuscripts collecting the latest scientific findings in terms of molecular mechanisms of action and biological function of melatonin and vitamin D as well as their metabolites or homologues. Papers aim to improve our understanding of the biological meaningful of these substances as well as involved signalling pathways. Original experimental research, review articles, and commentary articles on this and related topics are invited.

Dr. Konrad Kleszczyński
Prof. Dr. Andrzej Slominski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Melatonin
  • Metabolites of melatonin
  • Vitamin D
  • Vitamins
  • Melanoma
  • Skin Diseases
  • Cell Signalling
  • Mitochondria
  • Dermatoendocrinology
  • Skin Therapy

Published Papers (3 papers)

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Research

Article
1,25(OH)2D3 Inhibited Ferroptosis in Zebrafish Liver Cells (ZFL) by Regulating Keap1-Nrf2-GPx4 and NF-κB-hepcidin Axis
Int. J. Mol. Sci. 2021, 22(21), 11334; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222111334 - 20 Oct 2021
Viewed by 340
Abstract
Ferroptosis is a kind of iron-dependent programed cell death. Vitamin D has been shown to be an antioxidant and a regulator of iron metabolism, but the relationship between vitamin D and ferroptosis is poorly studied in fish. This study used zebrafish liver cells [...] Read more.
Ferroptosis is a kind of iron-dependent programed cell death. Vitamin D has been shown to be an antioxidant and a regulator of iron metabolism, but the relationship between vitamin D and ferroptosis is poorly studied in fish. This study used zebrafish liver cells (ZFL) to establish a ferroptosis model to explore the effect of 1,25(OH)2D3 on cell ferroptosis and its mechanism of action. The results showed that different incubation patterns of 1,25(OH)2D3 improved the survival rate of ZFL, mitigated mitochondrial damage, enhanced total glutathione peroxidase (GPx) activity, and reduced intracellular reactive oxygen species (ROS), lipid peroxidation (LPO), and malondialdehyde (MDA), as well as iron ion levels, with the best effect at 200 pM 1,25(OH)2D3 preincubation for 72 h. Preincubation of ZFL at 200 pM 1,25(OH)2D3 for 72 h downgraded keap1 and ptgs2 gene expression, increased nrf2, ho-1, fth1, gpx4a,b expression, and lowered the expression of the nf-κb p65,il-6,il-1β gene, thus reducing the expression of hamp1. The above results indicate that different incubation patterns of 1,25(OH)2D3 have protective effects on ferroptosis of ZFL induced by ferroptosis activator RSL3 and 1,25(OH)2D3 can inhibit ferroptosis of ZFL by regulating Keap1–Nrf2–GPx4 and NF-κB–hepcidin axis. Full article
(This article belongs to the Special Issue Melatonin and Vitamin D: Molecular Mechanisms and Biological Function)
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Article
17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model
Int. J. Mol. Sci. 2021, 22(16), 8926; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168926 - 19 Aug 2021
Viewed by 515
Abstract
Systemic sclerosis (SSc; scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)2pD, suppresses [...] Read more.
Systemic sclerosis (SSc; scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)2pD, suppresses fibrosis and mediators of the TGF-β1 pathway in the bleomycin (BLM) model of fibrosis. Fibrosis was induced into the skin of female C57BL/6 mice by repeated injections of BLM (50 μg/100 μL) subcutaneously. Mice received daily oral gavage with either vehicle (propylene glycol) or 17,20S(OH)2pD using 5, 15, or 30 μg/kg for 21 days. The injected skin was biopsied; analyzed histologically; examined for total collagen by Sircol; and examined for mRNA expression of MMP-13, BMP-7, MCP-1, Gli1, and Gli2 by TR-PCR. Spleen was analyzed for lymphocytes using flow cytometry. Serum was analyzed for cytokines using a multiplexed ELISA. Results showed that all three doses of 17,20S(OH)2pD suppressed net total collagen production, dermal thickness, and total collagen content in the BLM fibrosis model. 17,20S(OH)2pD also increased MMP-13 expression, decreased MCP-1 and Gli-2 expression in vivo, and suppressed serum levels of IL-13, TNF-α, IL-6, IL-10, IL-17, and IL-12p70. In summary, 17,20S(OH)2pD modulates the mediators of fibrosis in vivo and suppresses total collagen production and dermal thickness. This antifibrotic property of 17,20S(OH)2pD offers new therapeutic approaches for fibrotic disorders. Full article
(This article belongs to the Special Issue Melatonin and Vitamin D: Molecular Mechanisms and Biological Function)
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Article
Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing
Int. J. Mol. Sci. 2021, 22(11), 5658; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115658 - 26 May 2021
Cited by 3 | Viewed by 871
Abstract
The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin—a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance [...] Read more.
The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin—a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance for future therapies of cutaneous diseases. Mammalian skin is not only a prominent melatonin target, but also produces and rapidly metabolizes the multifunctional methoxyindole to biologically active metabolites. In our methodology, chitosan/collagen (CTS/Coll)-contained biomaterials are blended with melatonin at different doses to fabricate biomimetic hybrid scaffolds. We use rat tail tendon- and Salmo salar fish skin-derived collagens to assess biophysical and cellular properties by (i) Fourier transform infrared spectroscopy—attenuated total reflectance (FTIR–ATR), (ii) thermogravimetric analysis (TG), (iii) scanning electron microscope (SEM), and (iv) proliferation ratio of cutaneous cells in vitro. Our results indicate that melatonin itself does not negatively affect biophysical properties of melatonin-immobilized hybrid scaffolds, but it induces a pronounced elevation of cell viability within human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF), and reference melanoma cells. These results demonstrate that this indoleamine accelerates re-epithelialization. This delivery is a promising technique for additional explorations in future dermatotherapy and protective skin medicine. Full article
(This article belongs to the Special Issue Melatonin and Vitamin D: Molecular Mechanisms and Biological Function)
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