Special Issue "Advances in Membrane Protein Research"
Deadline for manuscript submissions: 31 December 2021.
Integral membrane proteins represent one-third of all open frames in sequenced genomes. This is in contrast to their immense importance in medicine, where an estimate of 60–70% of current drug targets are based on membrane proteins. To ensure adequate drug design, analysis of the structure and function of membrane proteins is essential. The advent of new tools and technologies for determining the structural biology of membrane proteins has led to a significant increase in the number of structures deposited to the Protein Data Bank during the past decade. Additionally, the “Resolution Revolution” brought about by single-particle Cryo-EM techniques continues to make progress, with the recently reported 1.7 Å resolution of the GABAA receptor structure. Nevertheless, our ability to take advantage of these methods is hindered in part by a lack of generally applicable methods for overexpression and purification, which are critical steps preceding functional and structural analysis. Thus, the bottlenecks prior to determining a membrane protein’s structure or characterizing its function remain. There is also an urgent need to improve the production of a sufficient amount of active membrane proteins. These limitations can be overcome through the development of new ideas, such as cell-free systems or amphipathic nanoparticles.
Prof. Dr. Dario Mizrachi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- integral membrane proteins
- structural determination
- function determination
- recombinant expression
- lipid vesicle
- lipid cubic phase
- amphipathic nanoparticles