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Special Issue "Signaling Systems in Membrane-Associated Proteins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Prof. Dr. Suzanne F. Scarlata
E-Mail Website
Guest Editor
Worcester Polytechnic Institute, Worcester, MA, USA
Interests: cell behavior; calcium signals; membrane-associated proteins; membrane properties; G protein signaling
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Biological membranes regulate communication between the external environment and internal compartments. Aside from serving as a barrier, the structure and content of the membrane itself plays a critical role in generating and propagating cellular signals. This issue examines the series of events that occur when extracellular information is received by plasma membrane and how this information generates various cascades of association/dissociation reactions between signaling molecules that lead to specific intracellular events. Changes in these protein interactions, along with concurrent intracellular signals, allow cells to proliferate, divide, migrate, and/or undergo morphological changes. The articles in this issue focus on signals occurring on the plasma and internal membranes that include enzymes that generate soluble second messengers, such as inositol phosphates, cAMP and Ca2+, as well as insoluble second messengers, such as diacylglycerol and phosphatidylinositide 4,5 bisphosphate. Articles will range from the interfacial association between proteins and the membrane surface that drive enzyme reaction dynamics to how cell membranes promote associations between peripheral proteins. Generation and enhancement of lipid signals and discussion of the properties specific to lipid modifying enzymes will be included. Importantly, the ability of these enzymes to communicate with associated signaling networks to drive cell function under normal and transformed conditions will be highlighted.

Prof. Dr. Suzanne Scarlata
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid membranes
  • lipid-modifying enzymes
  • membrane organization
  • interfacial activation
  • signaling complexes

Published Papers (1 paper)

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Review

Review
The Role of TRPM2 in Endothelial Function and Dysfunction
Int. J. Mol. Sci. 2021, 22(14), 7635; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147635 - 16 Jul 2021
Viewed by 519
Abstract
The transient receptor potential (TRP) melastatin-like subfamily member 2 (TRPM2) is a non-selective calcium-permeable cation channel. It is expressed by many mammalian tissues, including bone marrow, spleen, lungs, heart, liver, neutrophils, and endothelial cells. The best-known mechanism of TRPM2 activation is related to [...] Read more.
The transient receptor potential (TRP) melastatin-like subfamily member 2 (TRPM2) is a non-selective calcium-permeable cation channel. It is expressed by many mammalian tissues, including bone marrow, spleen, lungs, heart, liver, neutrophils, and endothelial cells. The best-known mechanism of TRPM2 activation is related to the binding of ADP-ribose to the nudix-box sequence motif (NUDT9-H) in the C-terminal domain of the channel. In cells, the production of ADP-ribose is a result of increased oxidative stress. In the context of endothelial function, TRPM2-dependent calcium influx seems to be particularly interesting as it participates in the regulation of barrier function, cell death, cell migration, and angiogenesis. Any impairments of these functions may result in endothelial dysfunction observed in such conditions as atherosclerosis or hypertension. Thus, TRPM2 seems to be an attractive therapeutic target for the conditions connected with the increased production of reactive oxygen species. However, before the application of TRPM2 inhibitors will be possible, some issues need to be resolved. The main issues are the lack of specificity, poor membrane permeabilization, and low stability in in vivo conditions. The article aims to summarize the latest findings on a role of TRPM2 in endothelial cells. We also show some future perspectives for the application of TRPM2 inhibitors in cardiovascular system diseases. Full article
(This article belongs to the Special Issue Signaling Systems in Membrane-Associated Proteins)
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