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Special Issue "Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Aleksandra Klimczak
E-Mail Website
Guest Editor
The Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy PAS, Wroclaw, Poland
Interests: mesenchymal stem cells (MSCs); MSCs secretome; microvesicles (MVs); MSCs and bioactive factors; regenerative medicine; cellular therapy; muscular dystrophy; wound healing

Special Issue Information

Dear Colleagues,

Mesenchymal stem/progenitor cells (MSCs) reside in many human tissues and organs and play important roles in tissue regeneration and tissue homeostasis. These cells can be isolated from different tissues of the adult human body, expanded in vitro and applied for the regeneration of tissues and organs damaged by age, disease or extensive injury. Cells bearing MSC characteristics differ in the facets of proliferation and differentiation, which results in their diverse biological potential and applications in tissue regeneration. Experimental studies have shown that not only MSCs, but also their derivates—such as a conditioned medium containing a variety of bioactive factors or extracellular vesicles (EVs) (microvesicles and exosomes) carrying various cytoplasmic components, including lipids, DNA fragments and RNA (including mRNA and microRNA)—contribute to tissue recovery and angiogenesis and modify the inflammatory microenvironment in a paracrine and endocrine manner. This Special Issue will present state-of-the-art studies on the therapeutic effects of various stem/progenitor cells and/or their derivates in the context of tissue and organ regeneration. The potential topics to be covered include (1) bioactive factors released by mesenchymal stem/progenitor cells for cell-free therapy in tissue regeneration, (2) extracellular vesicles from parental mesenchymal stem/progenitor cells for cell-free therapy in tissue regeneration and (3) the proangiogenic properties of bioactive factors and/or extracellular vesicles released by MSCs.

Prof. Aleksandra Klimczak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mesenchymal stem cells
  • Mesenchymal stem/progenitor cells
  • MSC secretome
  • Bioactive factors released by MSCs
  • MSC extracellular vesicles (EVs)
  • Cell-free therapy
  • Tissue regeneration
  • MSCs secretome and angiogenesis

Published Papers (1 paper)

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Open AccessArticle
Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration
Int. J. Mol. Sci. 2021, 22(8), 4064; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084064 - 14 Apr 2021
Viewed by 364
SmartBone® (SB) is a biohybrid bone substitute advantageously proposed as a class III medical device for bone regeneration in reconstructive surgeries (oral, maxillofacial, orthopedic, and oncology). In the present study, a new strategy to improve SB osteoinductivity was developed. SB scaffolds were [...] Read more.
SmartBone® (SB) is a biohybrid bone substitute advantageously proposed as a class III medical device for bone regeneration in reconstructive surgeries (oral, maxillofacial, orthopedic, and oncology). In the present study, a new strategy to improve SB osteoinductivity was developed. SB scaffolds were loaded with lyosecretome, a freeze-dried formulation of mesenchymal stem cell (MSC)-secretome, containing proteins and extracellular vesicles (EVs). Lyosecretome-loaded SB scaffolds (SBlyo) were prepared using an absorption method. A burst release of proteins and EVs (38% and 50% after 30 min, respectively) was observed, and then proteins were released more slowly with respect to EVs, most likely because they more strongly adsorbed onto the SB surface. In vitro tests were conducted using adipose tissue-derived stromal vascular fraction (SVF) plated on SB or SBlyo. After 14 days, significant cell proliferation improvement was observed on SBlyo with respect to SB, where cells filled the cavities between the native trabeculae. On SB, on the other hand, the process was still present, but tissue formation was less organized at 60 days. On both scaffolds, cells differentiated into osteoblasts and were able to mineralize after 60 days. Nonetheless, SBlyo showed a higher expression of osteoblast markers and a higher quantity of newly formed trabeculae than SB alone. The quantification analysis of the newly formed mineralized tissue and the immunohistochemical studies demonstrated that SBlyo induces bone formation more effectively. This osteoinductive effect is likely due to the osteogenic factors present in the lyosecretome, such as fibronectin, alpha-2-macroglobulin, apolipoprotein A, and TGF-β. Full article
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