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Foodomics: A New Comprehensive Approach to Food and Nutrition

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 8533

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Special Issue Editors

Dr. Andrea Scaloni

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Guest Editor

Proteomics & Mass Spectrometry Laboratory, ISPAAM-National Research Council, 80147 Naples, Italy
Interests: quantitative proteomics in biological tissues/body fluids of organisms having bioagricultural interest; functional proteomics; protein post-translational modifications; interactomics; redox proteomics; innovations in mass spectrometry, chromatography and electrophoresis

Dr. Gianluca Picariello

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Guest Editor

Institute of Food Sciences, ISA-National Research Council, 83100 Avellino, Italy
Interests: Proteomics and peptidomics of foods; Characterization of raw food ingredients; process-induced modifications and protein digestion in the human gastrointestinal tract; Bioaccessibility and biovailability of health-related proteins, peptides and fatty acids

Special Issue Information

Dear Colleagues,

Foodomics, as defined is a discipline that studies the food and nutrition domains through the application and integration of advanced omics technologies. Researchers in modern food science and nutrition used more advanced and multi-disciplinary strategies. These new approaches adopt well-established methodologies in medical, pharmacological, and/or biotechnological research, making use of advanced omics tools and bioinformatics, along with in-vitro, in-vivo and/or clinical assays. As a result of this trend, new interdisciplinary research areas such as nutrigenomics, nutrigenetics, nutritional genomics, nutritranscriptomics, nutriproteomics, nutrimetabolomics, microbiomics, toxicogenomics, and systems biology have emerged.

About ten years ago, this complex and interesting research field was originally termed Foodomics (Cifuentes A. 2009. Food analysis and Foodomics. J. Chromatogr. A 1216, 43: 7109). It is very probable that nobody at that time (including those who first used this term in a scientific article) imagined that in the future, this word would have been used by such a large number of scientists working in the field of food and nutrition sciences.

This Special Issue, devoted to “Foodomics: A New Comprehensive Approach to Food and Nutrition”, invites high-quality research papers/review articles on relevant food and nutrition science areas which focus on exploitation of food science in the light of an improvement of human nutrition.

As Guest Editors of this Special Issue of the International Journal of Molecular Sciences (https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms), it is our pleasure to invite you to submit an article on this topic. The article may be either a full paper based on your own research in this area, or may be a focused review article on some aspect of the subject. All submissions will be subject to peer review. If you plan to submit a review article, please provide us with a title and a brief description at your earliest convenience, in order to avoid multiple reviews covering the same field of investigation.

Dr. Andrea Scaloni
Dr. Gianluca Picariello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Foodomics
Metabolomics
Proteomics
genomics
transcriptomics
Food composition
Food quality and safety
Nutrition
Digestomics
Bioactive peptides
Food allergens

Published Papers (3 papers)

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Research

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17 pages, 2104 KiB

Open AccessArticle

Differential Protein Expression in Berry Skin from Red Grapes with Varying Hybrid Character

by Valentina Spada, Luigia Di Stasio, Pasquale Ferranti, Francesco Addeo, Gianfranco Mamone and Gianluca Picariello

Int. J. Mol. Sci. 2022, 23(3), 1051; https://doi.org/10.3390/ijms23031051 - 19 Jan 2022

Cited by 3 | Viewed by 1434

Abstract

Protein expression from the berry skin of four red grape biotypes with varying hybrid character was compared at a proteome-wide level to identify the metabolic pathways underlying divergent patterns of secondary metabolites. A bottom-up shotgun proteomics approach with label-free quantification and MaxQuant-assisted computational analysis was applied. Red grapes were from (i) purebred Vitis vinifera (Aglianico cv.); (ii) V. vinifera (local Sciascinoso cv.) grafted onto an American rootstock; (iii) interspecific hybrid (V. vinifera × V. labrusca, Isabel), and (iv) uncharacterized grape genotype with hybrid lineage, producing relatively abundant anthocyanidin 3,5-O-diglucosides. Proteomics supported the differences between hybrids and purebred V. vinifera grapes, consistently with distinct phenotypic metabolite assets. Methanol O-anthraniloyltransferase, which catalyses the synthesis of methyl anthranilate, primarily responsible for the “foxy” odour, was exclusive of the Isabel hybrid grape. Most of the proteins with different expression profiles converged into coordinated biosynthetic networks of primary metabolism, while many possible enzymes of secondary metabolism pathways, including 5-glucosyltransferases expected for hybrid grapes, remained unassigned due to incomplete protein annotation for the Vitis genus. Minor differences of protein expression distinguished V. vinifera scion grafted onto American rootstocks from purebred V. vinifera skin grapes, supporting a slight influence of the rootstock on the grape metabolism. Full article

(This article belongs to the Special Issue Foodomics: A New Comprehensive Approach to Food and Nutrition)

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18 pages, 2523 KiB

Open AccessArticle

Secondary Metabolic Profile as a Tool for Distinction and Characterization of Cultivars of Black Pepper (Piper nigrum L.) Cultivated in Pará State, Brazil

by Luccas M. Barata, Eloísa H. Andrade, Alessandra R. Ramos, Oriel F. de Lemos, William N. Setzer, Kendall G. Byler, José Guilherme S. Maia and Joyce Kelly R. da Silva

Int. J. Mol. Sci. 2021, 22(2), 890; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020890 - 17 Jan 2021

Cited by 14 | Viewed by 3438

Abstract

This study evaluated the chemical compositions of the leaves and fruits of eight black pepper cultivars cultivated in Pará State (Amazon, Brazil). Hydrodistillation and gas chromatography–mass spectrometry were employed to extract and analyze the volatile compounds, respectively. Sesquiterpene hydrocarbons were predominant (58.5–90.9%) in the cultivars “Cingapura”, “Equador”, “Guajarina”, “Iaçará”, and “Kottanadan”, and “Bragantina”, “Clonada”, and “Uthirankota” displayed oxygenated sesquiterpenoids (50.6–75.0%). The multivariate statistical analysis applied using volatile composition grouped the samples into four groups: γ-Elemene, curzerene, and δ-elemene (“Equador”/“Guajarina”, I); δ-elemene (“Iaçará”/“Kottanadan”/“Cingapura”, II); elemol (“Clonada”/“Uthirankota”, III) and α-muurolol, bicyclogermacrene, and cubebol (“Bragantina”, IV). The major compounds in all fruit samples were monoterpene hydrocarbons such as α-pinene, β-pinene, and limonene. Among the cultivar leaves, phenolics content (44.75–140.53 mg GAE·g⁻¹ FW), the enzymatic activity of phenylalanine-ammonia lyase (20.19–57.22 µU·mL⁻¹), and carotenoids (0.21–2.31 µg·mL⁻¹) displayed significant variations. Due to black pepper’s susceptibility to Fusarium infection, a molecular docking analysis was carried out on Fusarium protein targets using each cultivar’s volatile components. F. oxysporum endoglucanase was identified as the preferential protein target of the compounds. These results can be used to identify chemical markers related to the susceptibility degree of black pepper cultivars to plant diseases prevalent in Pará State. Full article

(This article belongs to the Special Issue Foodomics: A New Comprehensive Approach to Food and Nutrition)

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Review

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20 pages, 2739 KiB

Open AccessReview

The Role of High-Resolution Analytical Techniques in the Development of Functional Foods

by Álvaro Fernández-Ochoa, Francisco Javier Leyva-Jiménez, María De la Luz Cádiz-Gurrea, Sandra Pimentel-Moral and Antonio Segura-Carretero

Int. J. Mol. Sci. 2021, 22(6), 3220; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063220 - 22 Mar 2021

Cited by 7 | Viewed by 2476

Abstract

The approaches based on high-resolution analytical techniques, such as nuclear magnetic resonance or mass spectrometry coupled to chromatographic techniques, have a determining role in several of the stages necessary for the development of functional foods. The analyses of botanical extracts rich in bioactive compounds is one of the fundamental steps in order to identify and quantify their phytochemical composition. However, the compounds characterized in the extracts are not always responsible for the bioactive properties because they generally undergo metabolic reactions before reaching the therapeutic targets. For this reason, analytical techniques are also applied to analyze biological samples to know the bioavailability, pharmacokinetics and/or metabolism of the compounds ingested by animal or human models in nutritional intervention studies. In addition, these studies have also been applied to determine changes of endogenous metabolites caused by prolonged intake of compounds with bioactive potential. This review aims to describe the main types and modes of application of high-resolution analytical techniques in all these steps for functional food development. Full article

(This article belongs to the Special Issue Foodomics: A New Comprehensive Approach to Food and Nutrition)

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