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Special Issue "The Role of Secondary Metabolites in Inflammation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editor

Dr. Jens Staal
E-Mail Website
Guest Editor
Ghent University, Ghent, Belgium
Interests: inflammation; immunity; signal transduction; molecular evolution; reporter systems; genetic models; abscisic acid; salicylic acid; indole-3-acetic acid; cytokinins

Special Issue Information

Dear Colleagues,

Secondary (or specialized) metabolites is a very broad term for a variety of small molecules that often have profound physiological effects. Common for many of these molecules is that they regulate inflammation, and often the interaction between primary metabolism and inflammation, but the exact mechanism is often poorly understood. Some secondary metabolites are well-known hormones, such as those originating from steroid biosynthesis (glucocorticoids, sex hormones, etc.) or from amino acid metabolism (serotonin, dopamine, etc.), and other well-known molecules, such as kyneurins and prostaglandins. Lesser-known secondary metabolites that are also endogenously generated are the classical plant hormones abscisic acid (ABA), cytokinins (CKs), indole-3-acetic acid (Auxin), and salicylic acid (SA). For many of these molecules, elucidating their roles is further complicated by the fact that they may originate from several different sources, such as endogenous biosynthesis, microbiota, or nutrition.

We warmly welcome submissions, including original papers and reviews, investigating the signaling effects from secondary metabolites and their effect on inflammation and inflammation-related diseases.

Dr. Jens Staal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inflammation
  • immunometabolism
  • specialized metabolism
  • secondary metabolites
  • small molecules
  • hormones
  • homeostasis

Published Papers

This special issue is now open for submission.
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