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The Emerging Role of Metal Complex Materials in Pharmaceutical Design...
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The Emerging Role of Metal Complex Materials in Pharmaceutical Design and Delivery

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7577

Special Issue Editor

Dr. Michael Danquah

E-Mail Website
Guest Editor
Department of Chemical Engineering, University of Tennessee, Chattanooga, TN, USA
Interests: nanoscience; nanomedicine; targeted drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Recently, metal complex materials have gained research attention in the design and delivery of a variety of pharmaceutical ingredients. Conventional metallic materials, including nanosized metals, used for pharmaceutical applications are usually challenged with high toxicity in addition to poor hydration stability and low solubility and dissolution rates. Coordination complex formation via a combination of chelating agents such as nicotinic acid, pyrazinamide, captopril, guanfacine, etc with transition metals have been explored to address some of the limitations of free metallic materials in pharmaceutical applications. The introduction of a deficient metal ion body, the use of ligands as antidotes to metal-based poisoning, and the pharmacotherapy effect of blocking metal ions required for specific enzymatic activities are some of the benefits of metal complex materials in pharmaceutical applications. However, there still exist several physicochemical challenges that need to be addressed to unlock the full potential of metal complex materials, particularly in relation to the complexity of their synthesis process, biocompatibility, and the level of reduced toxicity. Hence, more research investment is needed to improve the pharmaceutical applications of metal complex materials.

This Special Issue focuses on recent advances in the synthesis, characterization, functionalization, and pharmaceutical applications of metal complex materials. We welcome studies focused on emerging metal complexes, synthesis and characterization apporaches, theoretical simulations, and pharmaceutical applications in drug design and delivery. Both Original Research articles and Reviews can be submitted:

  • Synthesis and characterization of novel metal complex materials
  • Strategies to enhance the pharmaceutical properties of metal complex materials
  • Metal complex-based drug formulations for targeted and controlled delivery
  • Advanced smart and functional metal complexes with enhanced drug entrapment efficiency
  • Computational approaches to metal complex material formation and analysis
  • Functionalization of metal complex materials for pharmaceutical applications
  • New pharmaceutical applications of metal complex materials
  • Mechanism of action of metal complex materials in pharmaceutical applications
  • Toxicity analysis of metal complex materials in pharmaceutical applications
  • Large-scale production of metal complex materials for therapeutic applications

Dr. Michael Danquah
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metal complexes;
  • Pharmaceutical design;
  • Crystals;
  • Pharmaceutical delivery;
  • Transition metals;
  • Medicinal chemistry;
  • Metal dopants

Published Papers (3 papers)

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Research

22 pages, 5264 KiB  
Article
Development and In Vitro and In Vivo Evaluation of an Antineoplastic Copper(II) Compound (Casiopeina III-ia) Loaded in Nonionic Vesicles Using Quality by Design
by Zenayda Aguilar-Jiménez, Mauricio González-Ballesteros, Silvia G. Dávila-Manzanilla, Adrián Espinoza-Guillén and Lena Ruiz-Azuara
Int. J. Mol. Sci. 2022, 23(21), 12756; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232112756 - 22 Oct 2022
Cited by 4 | Viewed by 2013
Abstract
In recent decades, the interest in metallodrugs as therapeutic agents has increased. Casiopeinas are copper-based compounds that have been evaluated in several tumor cell lines. Currently, casiopeina III-ia (CasIII-ia) is being evaluated in phase I clinical trials. The aim of the present work [...] Read more.
In recent decades, the interest in metallodrugs as therapeutic agents has increased. Casiopeinas are copper-based compounds that have been evaluated in several tumor cell lines. Currently, casiopeina III-ia (CasIII-ia) is being evaluated in phase I clinical trials. The aim of the present work is to develop a niosome formulation containing CasIII-ia for intravenous administration through a quality-by-design (QbD) approach. Risk analysis was performed to identify the factors that may have an impact on CasIII-ia encapsulation. The developed nanoformulation optimized from the experimental design was characterized by spectroscopy, thermal analysis, and electronic microscopy. In vitro drug release showed a burst effect followed by a diffusion-dependent process. The niosomes showed physical stability for at least three months at 37 °C and 75% relative humidity. The in vitro test showed activity of the encapsulated CasIII-ia on a metastatic breast cancer cell line and the in vivo test of nanoencapsulated CasIII-ia maintained the activity of the free compound, but showed a diminished toxicity. Therefore, the optimal conditions obtained by QbD may improve the scaling-up process. Full article
(This article belongs to the Special Issue The Emerging Role of Metal Complex Materials in Pharmaceutical Design and Delivery)
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18 pages, 8112 KiB  
Article
Graphene Oxide Loaded on TiO2-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts
by Xu Cao, Keyi Wu, Caiyun Wang, Yatong Guo, Ran Lu, Xin Wang and Su Chen
Int. J. Mol. Sci. 2022, 23(15), 8723; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23158723 - 05 Aug 2022
Cited by 4 | Viewed by 1454
Abstract
Surface topography, protein adsorption, and the loading of coating materials can affect soft tissue sealing. Graphene oxide (GO) is a promising candidate for improving material surface functionalization to facilitate soft tissue integration between cells and biomaterials. In this study, TiO2 nanotubes (TNTs) [...] Read more.
Surface topography, protein adsorption, and the loading of coating materials can affect soft tissue sealing. Graphene oxide (GO) is a promising candidate for improving material surface functionalization to facilitate soft tissue integration between cells and biomaterials. In this study, TiO2 nanotubes (TNTs) were prepared by the anodization of Ti, and TNT-graphene oxide composites (TNT-GO) were prepared by subsequent electroplating. The aim of this study was to investigate the effect of TNTs and TNT-GO surface modifications on the behavior of human gingival fibroblasts (HGFs). Commercially pure Ti and TNTs were used as the control group, and the TNT-GO surface was used as the experimental group. Scanning electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction were used to perform sample characterization. Cell adhesion, cell proliferation, cell immunofluorescence staining, a wound-healing assay, real-time reverse-transcriptase polymerase chain reaction (RT-PCR), and Western blotting showed that the proliferation, adhesion, migration, and adhesion-related relative gene expression of HGFs on TNT-GO were significantly enhanced compared to the control groups, which may be mediated by the activation of integrin β1 and the MAPK-Erk1/2 pathway. Our findings suggest that the biological reactivity of HGFs can be enhanced by the TNT-GO surface, thereby improving the soft tissue sealing ability. Full article
(This article belongs to the Special Issue The Emerging Role of Metal Complex Materials in Pharmaceutical Design and Delivery)
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13 pages, 5302 KiB  
Article
Polyurethane Foam Incorporated with Nanosized Copper-Based Metal-Organic Framework: Its Antibacterial Properties and Biocompatibility
by Do Nam Lee, Kihak Gwon, Yunhee Nam, Su Jung Lee, Ngoc Minh Tran and Hyojong Yoo
Int. J. Mol. Sci. 2021, 22(24), 13622; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222413622 - 19 Dec 2021
Cited by 13 | Viewed by 3410
Abstract
Polyurethane foams (PUFs) have attracted attention as biomaterials because of their low adhesion to the wound area and suitability as biodegradable or bioactive materials. The composition of the building blocks for PUFs can be controlled with additives, which provide excellent anti-drug resistance and [...] Read more.
Polyurethane foams (PUFs) have attracted attention as biomaterials because of their low adhesion to the wound area and suitability as biodegradable or bioactive materials. The composition of the building blocks for PUFs can be controlled with additives, which provide excellent anti-drug resistance and biocompatibility. Herein, nanosized Cu-BTC (copper(II)-benzene-1,3,5-tricarboxylate) was incorporated into a PUF via the crosslinking reaction of castor oil and chitosan with toluene-2,4-diisocyanate, to enhance therapeutic efficiency through the modification of the surface of PUF. The physical and thermal properties of the nanosized Cu-BTC-incorporated PUF (PUF@Cu-BTC), e.g., swelling ratio, phase transition, thermal gravity loss, and cell morphology, were compared with those of the control PUF. The bactericidal activities of PUF@Cu-BTC and control PUF were evaluated against Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus. PUF@Cu-BTC exhibited selective and significant antibacterial activity toward the tested bacteria and lower cytotoxicity for mouse embryonic fibroblasts compared with the control PUF at a dose of 2 mg mL−1. The Cu(II) ions release test showed that PUF@Cu-BTC was stable in phosphate buffered saline (PBS) for 24 h. The selective bactericidal activity and low cytotoxicity of PUF@Cu-BTC ensure it is a candidate for therapeutic applications for the drug delivery, treatment of skin disease, and wound healing. Full article
(This article belongs to the Special Issue The Emerging Role of Metal Complex Materials in Pharmaceutical Design and Delivery)
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