Special Issue "Metallodrugs: Mechanisms of Action, Molecular Targets and Biological Activity"
Deadline for manuscript submissions: 15 July 2021.
Interests: protein-metal based drug adducts; X-Ray crystallography; protein metalation; protein-ligand interactions
Special Issues and Collections in MDPI journals
Since the serendipitous discovery of the cytotoxic activity of cisplatin at the end of the 1960s, Pt- and non-Pt-based compounds have been extensively studied as potential anticancer agents. Metal compounds also play an important role in clinics as antimicrobial, antiviral or antiarthritic agents. A deep knowledge of their mode of action and of their biological targets may help in the design of new molecules with improved biological activities and limited side effects.
This Special Issue of International Journal of Molecular Science on “Metallodrugs: mechanisms of action, molecular targets and biological activity” aims to collect original contributions, letters or review articles describing recent advances in this field.
Topics include, but are not limited to, the synthesis and characterization, including structures and applications, of novel metal compounds with biological activities, insights into stability and reactivity of these compounds, insights into the mechanism of action, potential targets, and biological activity of metallodrugs. The Issue will also collect articles describing the interaction of metallodrugs with biological macromolecules, based on experimental techniques (NMR, X-ray crystallography, mass spectrometry etc.) or using computational approaches.
Prof. Dr. Antonello Merlino
Dr. Giarita Ferraro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Metal-based drugs
- Protein metalation
- Coordination chemistry
- Metal binding sites
- Organometallic compounds