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Special Issue "Molecular Mechanisms in the Microbiome–Brain–Gut Axis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Gerard M. Moloney
E-Mail Website
Guest Editor
University College, Cork, Ireland
Interests: microRNA; microbiota; brain; gut; non-coding

Special Issue Information

Dear colleagues,

The gut microbiome enables a constant transfer of information between the gut and the brain and there are many unexplored molecular pathways underpinning this transfer.  The aim of this special edition will be to harness the key current research in the field into a compelling collection of novel research in the field.

This scope of this special edition will be novel research that examines how key unexplored molecular pathways influence the gut microbiome, the brain, and the gut, preferably showing an interaction between the different nodes of this relationship. The preferred theme of the research will be from a molecular biology point of view with mechanistic experiments consisting of either an in-vitro, in-silico or in-vivo nature forming the overall structure of submissions. Furthermore, this special edition will outline how the key nodes of the Microbiome-Brain-Gut Axis when disturbed, influence disease in the gut or the brain. Finally, it is hoped that of the articles submitted, some will show how therapeutic interventions targeting one aspect of the Microbiome-Brain-Gut Axis can repair other points along the axis. For example, can modulating the composition of the microbiome, influence the function of the brain via chemical or probiotic intervention (amongst many more).

Dr. Gerard M. Moloney
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

Review
The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17
Int. J. Mol. Sci. 2021, 22(1), 118; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010118 - 24 Dec 2020
Cited by 3 | Viewed by 1219
Abstract
Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in social interaction and repetitive behavior. The disease is thought to develop from changes in brain development at an early age, although the exact mechanisms are not known yet. [...] Read more.
Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in social interaction and repetitive behavior. The disease is thought to develop from changes in brain development at an early age, although the exact mechanisms are not known yet. In addition, a significant number of people with ASD develop problems in the intestinal tract. A Disintegrin And Metalloproteases (ADAMs) include a group of enzymes that are able to cleave membrane-bound proteins. ADAM10 and ADAM17 are two members of this family that are able to cleave protein substrates involved in ASD pathogenesis, such as specific proteins important for synapse formation, axon signaling and neuroinflammation. All these pathological mechanisms are involved in ASD. Besides the brain, ADAM10 and ADAM17 are also highly expressed in the intestines. ADAM10 and ADAM17 have implications in pathways that regulate gut permeability, homeostasis and inflammation. These metalloproteases might be involved in microbiota-gut–brain axis interactions in ASD through the regulation of immune and inflammatory responses in the intestinal tract. In this review, the potential roles of ADAM10 and ADAM17 in the pathology of ASD and as targets for new therapies will be discussed, with a focus on the gut–brain axis. Full article
(This article belongs to the Special Issue Molecular Mechanisms in the Microbiome–Brain–Gut Axis)
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