Special Issue "Tumor Microenvironment in Colorectal Cancer"
Deadline for manuscript submissions: 31 October 2021.
2. Centro de Investigación Biomédica en Red de Cancer (CIBERONC), 28029 Madrid, Spain
Interests: tumor microenvironment; colorectal cancer; cancer-associated fibroblasts; exosomes; migration and invasion; tumor biomarkers
Experimental studies and analyses of clinical material have convincingly demonstrated that colorectal cancer initiation, growth, and progression do not depend exclusively on cell-autonomous properties of cancer cells themselves but are also deeply influenced by the local microenvironment. The stromal elements of tumors consist of a variety of non-epithelial cell types and their interactions which involve reciprocal paracrine signaling, including growth factors, exosomes, and extracellular matrix components.
Extracellular matrix, blood vessels, immune cells, and fibroblasts are the main components of what is known as the tumor microenvironment. Fibroblasts are one of the most abundant and active cell types of the tumor microenvironment. Fibroblast-like cells, usually named as cancer-associated fibroblasts (CAFs), seem to regulate many aspects of tumorigenesis and can exert tumor-suppressing and -promoting effects, involving interactions between the malignant cells and other cells of the tumor microenvironment. Moreover, CAFs actively participate in extracellular matrix deposition and remodeling, which are also related to disease progression.
In addition, endothelial cells play the role of communicating tumor cells with surrounding areas by generating new vascular networks or modifying pre-existing vessels, thus conditioning tumor oxygen and nutrient supply. Since endothelial cells, as well as CAFs and tumor cells, affect immune cell recruitment within the tumor, it can be assumed that the tumor microenvironment will condition immune response. T-cell activation can end up either stimulating or inhibiting the immune system, depending on many factors, such as tumor antigen production, regulation of inhibitory ligands, angiogenesis, CAFs’ chemokine secretion, etc.
This Special Issue will include papers investigating the different mechanisms related with tumor microenvironment involved in CRC initiation, growth, and progression. Furthermore, experimental clinical and preclinical studies including bimolecular experiments to examine potential new approaches for CRC patients’ survival increase and improvement are welcome.
This Special Issue welcomes original research and review papers. Potential topics include but are not limited to the following:
- Molecular mechanisms of tumor microenvironment cross-talk in CRC;
- Epigenetic regulation of tumor microenvironment in CRC;
- Molecular imaging approaches to study tumor microenvironment in CRC;
- Tumor biomarkers related with tumor microenvironment in CRC patients;
- “Omics” studies of tumor microenvironment components in CRC;
- Therapeutic approaches of CRC patients based in the tumor microenvironment target.
Dr. Cristina Peña
Manuscript Submission Information
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- Colorectal cancer
- Tumor microenvironment
- Cancer-associated fibroblasts
- Endothelial cells
- Immune cells
- Extracellular matrix
- Tumor microenvironment biomarkers
- Tumor microenvironment-based clinical approaches