Special Issue "Recent Advances in Microgravity and Cell Adherence"
Deadline for manuscript submissions: 31 August 2021.
Interests: cell adhesion; organoid formation; data evaluation
Special Issues and Collections in MDPI journals
The adhesion behavior of many types of cells changes when gravity forces affecting these cells are modified during their growth in space or on special devices which change the gravity vector continuously. According to current knowledge, these changes are accompanied by alterations in quantities, localization, and/or posttranslational modification of a considerable number of proteins. In recent years, many attempts have been made to determine how the lack of the rather small force of 1g that pulls cells constantly to the center of the earth is transformed into physiological reactions which, together, induce an alteration in the behavior of whole cells. These efforts suggested a complicated interplay of changes in protein conformation, complex formation and enzymatic activities. However, this suggestion requires substantiation. It is of special interest to identify the various changes and observe how they are linked together. This will help to distinguish between primary and secondary reactions and finally lead to finding a target of gravity force.
Articles and reviews will be collected in which mechanisms are unveiled regarding the alterations of proteins caused by the modification of gravity force which subsequently influence physiologic reactions that lead to a modified regulation of cell adhesion and growth under microgravity.
Dr. Johann Bauer
Manuscript Submission Information
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- Cell monolayer
- Organoid formation
- Adhesion proteins
- Tight junction