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Special Issue "Recent Advances in Microgravity and Cell Adherence"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Johann Bauer
E-Mail
Guest Editor
SiHaTho GmbH, Biedenkopf, Germany
Interests: cell adhesion; organoid formation; data evaluation
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The adhesion behavior of many types of cells changes when gravity forces affecting these cells are modified during their growth in space or on special devices which change the gravity vector continuously. According to current knowledge, these changes are accompanied by alterations in quantities, localization, and/or posttranslational modification of a considerable number of proteins. In recent years, many attempts have been made to determine how the lack of the rather small force of 1g that pulls cells constantly to the center of the earth is transformed into physiological reactions which, together, induce an alteration in the behavior of whole cells. These efforts suggested a complicated interplay of changes in protein conformation, complex formation and enzymatic activities. However, this suggestion requires substantiation. It is of special interest to identify the various changes and observe how they are linked together. This will help to distinguish between primary and secondary reactions and finally lead to finding a target of gravity force.

Articles and reviews will be collected in which mechanisms are unveiled regarding the alterations of proteins caused by the modification of gravity force which subsequently influence physiologic reactions that lead to a modified regulation of cell adhesion and growth under microgravity.

Dr. Johann Bauer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cell monolayer
  • Organoid formation
  • Adhesion proteins
  • Tight junction

Published Papers (1 paper)

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Research

Open AccessArticle
Simulated Microgravity Inhibits the Proliferation of Chang Liver Cells by Attenuation of the Major Cell Cycle Regulators and Cytoskeletal Proteins
Int. J. Mol. Sci. 2021, 22(9), 4550; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094550 - 27 Apr 2021
Viewed by 272
Abstract
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under [...] Read more.
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins. Full article
(This article belongs to the Special Issue Recent Advances in Microgravity and Cell Adherence)
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