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Special Issue "Mitochondria and Mitochondrial Carriers in Cancer and Rare Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Dr. Francesco De Leonardis
Guest Editor
Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario "Ernesto Quagliariello", University of Bari "Aldo Moro", Bari, Italy
Interests: mitochondria; mitochondrial calcium regulation; mitochondrial carrier; Uncoupling proteins and Cancer; Reconstitution of mitochondrial carrier in vitro and functional study

Special Issue Information

Dear Colleagues,

Mitochondria are double‐membrane‐bound organelles that are present in all nucleated eukaryotic cells and are responsible for the production of cellular energy in the form of adenosine triphosphate (ATP).

Mitochondrial carriers (MCs) are a superfamily of nuclear-encoded proteins that are mostly localized in the inner mitochondrial membrane and transport numerous metabolites, nucleotides, cofactors, and inorganic anions.

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell. Although mutations in mitochondrial genes are common in cancer cells, they do not inactivate mitochondrial energy metabolism but rather alter the mitochondrial bioenergetic and biosynthetic state.

Lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and the function and interplay between the factors that transform the organelle from cell preservation to cell death compromise the development of new mitochondria-targeted approaches to treat human diseases.

Mutations in over 250 genes have now been shown to cause mitochondrial disease, and the biochemical, histochemical, immunocytochemical, and neuropathological characterization of these patients has led to improved diagnostic testing strategies and novel diagnostic techniques.

In this Special issue, we encourage the submission of manuscripts providing new and innovative therapeutic insights as well as papers describing technologies and models developed for the discovery of new mitochondrial target approaches in cancer and mitochondrial diseases. Systematic and perspective reviews are also welcome.

Dr. Francesco De Leonardis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondrial transport proteins (MTPs)
  • mitochondrial carriers
  • mitochondrial biogenesis
  • mitochondrial metabolism
  • mitochondrial gene expression
  • mitochondrial cell death and diseases
  • mitochondrial respiration
  • mitochondrial permeability transition
  • mitochondrial ROS
  • mitochondria-targeted therapy
  • mitochondrial carriers and cancer
  • cancer therapeutics
  • targeted therapy
  • drug discovery
  • gain/loss of function screening
  • cancer cell metabolism
  • tumor–microenvironment interactions

Published Papers

This special issue is now open for submission.
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