Special Issue "Molecular Research on Mitochondrial Dysfunction"
Deadline for manuscript submissions: 30 April 2021.
Interests: mitochondria; complexomic analysis; crisate remodelling; nucleoid dynamics; mitochondrial disease
Interests: mitochondrial disease; AAV; gene therapy; mitochondrial biology; mitochondrial DNA
It is becoming increasingly clear and widely accepted that mitochondria play a central role in human pathology, not only in relation to primary OxPhos defects but also in a wide range of diseases, including neurodegenerative and immunological disorders. However, how central homeostatic and signalling pathways, such as mitophagy, fusion–fission, and mtDNA heteroplasmy levels, impact on the onset and progression of these diseases has only recently started to emerge. Thus, this is an exciting and thrilling new subject of investigation. Contributions to this Special Issue will provide a general overview and critical insight on our current understanding of these aspects. Our hope is to open a forum where the molecular mechanisms and pathophysiological consequences of mitochondrial dysfunction will be debated with the final aim of increassing our understanding of this emerging and exciting branch of mitochondrial biology and pathophysiology.
Dr. María Eugenia Soriano
Dr. Carlo Viscomi
Manuscript Submission Information
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- mitochondrial dysfunction
- fusion-fission unbalance
- oxidative phosphorilation