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Special Issue "Multiple Enzyme Mechanism and Functions in Mitochondrial Biology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Fabiana Trombetti
E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, Alma Mater Studiorum - Università di Bologna, Bologna, Italy
Interests: Mitochondrial enzymes; mitochondrial biogenesis; mitochondrial metabolism
Prof. Dr. Salvatore Nesci
E-Mail Website
Guest Editor
Department of Veterinary Medical Sciences, Alma Mater Studiorum - Università di Bologna, Bologna, Italy
Interests: F1FO-ATPase; mitochondria; bioenergetics; permeability transition pore; biochemistry; cellular metabolism
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Mitochondria are dynamic and signalling organelles that regulate a wide variety of cellular functions and can dictate cell fate. They house the major enzymatic systems used to complete the oxidation of sugars, fats and proteins to produce ATP, but they play a vital role also in biosynthetic pathways and can rapidly adjust to meet the metabolic needs of the cell. Important byproducts of mitochondrial electron transport are reactive oxygen species which at low levels can act in cell signalling pathways. These radicals are balanced by strong mitochondrial antioxidant defence systems to prevent oxidative damage. Mitochondria are also involved in regulated cell death through activation of the mitochondrial permeability transition pore. Mitochondrial dynamics, which include mitochondrial fission, fusion and biogenesis, governs mitochondrial function and localization within the cell. All these processes involve the correct functioning of many enzymes whose activity is often regulated by post-translational modifications and mitochondrial dysfunctions can therefore also lead to various diseases. Knowledge of the enzyme mechanisms and regulation can therefore play an important role also in the identification of new pharmacological therapies.

In this Special Issue, we encourage the submission of manuscripts that improve and update knowledge in mitochondrial function and related enzyme mechanism to deepen their role in health and disease and reveal novel mitochondria-targeting therapeutic opportunities. Topical reviews on these topics are also welcome.

Dr. Fabiana Trombetti
Prof. Dr. Salvatore Nesci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mitochondrial enzymes
  • mitochondrial biogenesis
  • mitochondrial metabolism
  • mitochondrial respiration
  • mitochondrial permeability transition
  • mitochondrial cell death and diseases
  • mitochondrial ROS
  • mitochondria-targeted therapy
  • drug discovery
  • ATP synthase

Published Papers

This special issue is now open for submission.
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