Special Issue "Mitochondrial Metabolism in Cancer"
Deadline for manuscript submissions: 30 November 2021.
Interests: Cell differentiation; Cancer; Cancer Cell metabolism; Mitochondria; Mitochondrial Metabolism; Oxidative phosphorylation; Tumor markers; Warburg effect
Dipartimento di Medicina di Laboratorio, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L.go A. Gemelli 8, 00168 Roma, Italy
Interests: Mitochondria, Anthracyclines, Cardiotoxicity
Mitochondrial contribution to the pathogenesis of cancer has tended to be neglected for many years. In fact, Warburg's original observation that cancer cell preferentially uses glycolysis for energetic and anabolic purposes, producing large quantities of lactic acid, due to impaired mitochondrial function led for a long time to neglect the role of mitochondria in the pathophysiology of cancer, confining them to a simple secondary role, i.e. a damaged and hypofunctional organelle. Over time, it has become evident that the strongly induced aerobic glycolitic state of cancer cells is only a tip of an iceberg, one aspect of a more complex metabolic rearrangement aimed to satisfy high energy demands of cells during oncogenesis process. In this context, in which cancer cell singularly reprograms its metabolism to support the new needs for a rapid and uncontrolled proliferation, mitochondria have been recognized to play a crucial role not only in tumor formation but also in its progression. Besides being the powerhouse of the cell, as they have classically described, mitochondria control calcium homeostasis and thermogenesis, regulate cell death by apoptosis, contribute to transcriptional regulation and influence different signal transduction pathways by producing ROS, thus promoting genomic instability and cancer cell dissemination. In the light recent findings assigning an active and crucial role to mitochondrial physiology in cancer cell metabolism, this special issue on “Mitochondrial metabolism in cancer” aims to explore the various aspects of the tight connection between mitochondrial bioenergetics and tumourigenesis, by defining how the different mitochondrial activities could support cancer cell proliferation and identifying the mechanisms through which mitochondria can influence malignant transformation and tumor progression. Elucidating molecular relationships between mitochondria and cancer is essential step to realize new therapeutic strategies of targeting mitochondrial metabolism for cancer therapy.
Dr. Patrizia Bottoni
Manuscript Submission Information
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- Cancer Cell Metabolism
- Cancer Therapy
- Mitochondrial Metabolism
- Warburg Effect