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Special Issue "Frontiers in Molecular Biology of Brain Tumors"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Maurizio Salvati
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Guest Editor
Department of Neurosurgery, Policlinico Tor Vergata, Rome, Italy
Interests: neuro-oncology; brain tumors
Special Issues and Collections in MDPI journals
Prof. Dr. Antonio Santoro
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Guest Editor
Department of Neurosurgery, Neuromed, IRCCS, Sapienza University of Rome, Pozzilli, Italy
Interests: brain aneurysms; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery; skull base neurosurgery
Special Issues and Collections in MDPI journals
Prof. Dr. Alessandro Frati
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Guest Editor
Department of Neurosurgery, Neuromed, IRCCS, Sapienza University of Rome, Pozzilli, Italy
Interests: gliobastoma; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery
Dr. Alessandro Pesce
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Guest Editor
Human Neurosciences Department Neurosurgery Division, “Sapienza” University, Rome, Italy
Interests: gliobastoma; brain metastsis; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery
Dr. Daniele Armocida
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Guest Editor
Human Neurosciences Department Neurosurgery Division, Department of Neurosurgery, “Sapienza” University, Rome, Italy
Interests: gliobastoma; brain metastsis; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery
Dr. Placido Bruzzaniti
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Guest Editor
Fabrizio Spaziani Hospital, Frosinone, Italy
Interests: gliobastoma; brain metastsis; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery

Special Issue Information

Dear Colleagues,

In the last decade, great improvements in the understanding of the molecular basis of both primary and metastatic brain tumors have brought critical improvement and a subsequent dramatic impact on their clinical management. Compelling evidence has demonstrated the critical role played by the molecular pattern of brain tumors on the final oncologic prognosis. With regard to intrinsic brain tumors (IBT), further developments have outlined the role of factors such as focal hypoxia, the VEGF signaling system, mitochondrial metabolism, and intracellular and transmembrane G-protein coupled receptors in the mitotic drive of neoplastic cells. Furthermore, the mechanism determining the migration along the fibers of the white matter tracts have provided in-depth explanations of the invasiveness of IBTs. With regard to brain metastases (BM), outstanding proof has shed a light over a potential role of adhesion molecules, reactive species of oxygen, and even lymphatic extracranial cells over the intracranial diffusion of the disease.

Therefore, it is our pleasure to invite investigators to contribute to this Special Issue with original research articles as well as review and meta-analysis articles aimed at promoting the diffusion of the current knowledge of the molecular basis of neuro-oncological practice. We are particularly interested in articles describing new insights into pathophysiological mechanisms, conveying potentially useful insights to achieve original diagnostic and therapeutic approaches.

Potential topics include but are not limited to the following:

  • Molecular insights of glioblastoma and intrinsic brain tumor pathogenesis;
  • Molecular insights concerning brain metastases pathogenesis and their diffusion inside the intracranial compartment;
  • Clinical and surgical translations of the latest pathophysiological findings;
  • Molecular prognostic factors in glioblastoma and intrinsic brain tumors;
  • Molecular prognostic factors in brain metastases;
  • Novel research approaches in primary or metastatic brain tumor investigations;
  • Nutraceuticals and brain tumors;
  • Autophagy related to the biology of gliomas.

Prof. Dr. Maurizio Salvati
Prof. Dr. Antonio Santoro
Prof. Dr. Alessandro Frati
Dr. Alessandro Pesce
Dr. Daniele Armocida
Dr. Placido Bruzzaniti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Glioblastoma
  • Intrinsic brain tumor pathogenesis
  • Low-grade gliomas
  • Spinal intramedullary tumors
  • Brain metastases
  • Molecular pathogenesis of primary brain tumors
  • Molecular pathogenesis of brain metastases

Published Papers

This special issue is now open for submission.
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