Special Issue "Molecular Mechanisms of Cerebrovascular Diseases"
Deadline for manuscript submissions: 30 June 2021.
2. Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA
Interests: blood brain barrier; stroke; neuroinflammation; vascular malformation; aging; neurodegeneration; cell junctionas; epigenetics
Interests: hemorragic stroke; ischemic stroke; blood brain barrier; Blod-CSF barrier neuroinflamamation
Cerebrovascular diseases are a heterogenous group of disorders that affect brain vasculature structure and cerebral blood flow regulation. The common pathological event related to cerebrovascular diseases is stroke, manifested as a sudden cessation of blood flow due to vessel occlusion (ischemic stroke), transient occlusion with recovery (transient ischemic attack), or vessel rupture (hemorrhagic stroke). Brain endothelial cell dysfunction, vessel wall deterioration, and perivascular environment remodeling are major pathological substrates in cerebrovascular diseases. A wide variety of conditions, risk factors, and disorders lead to cerebrovascular diseases, although the underlying molecular mechanisms remain enigmatic. This Special Issue, entitled “Molecular Mechanisms of Cerebrovascular Diseases”, is focused on the molecular mechanisms of endothelial dysfunction and perivascular environment remodeling that lead to lodging of thromboemboli, vessel occlusion and rupture, the mechanism of aging and metabolic vascular wall degeneration, vascular injury and remodeling in sporadic and inherited vascular malformations, and mechanisms of impaired cerebral autoregulation. In addition to “traditional” mechanisms (e.g., inflammation, oxidative stress), this Special Issue welcomes articles that provide an overview of the role of epigenetics, mechanotransduction, and mitochondrial molecular mechanisms in the pathogenesis of cerebrovascular diseases. Studies on the molecular mechanisms associated with cerebral small vessel disease, both sporadic and inherited (i.e., CADASIL and CARASIL), as well as rare disorders, such as MoyaMoya, venous angioma, and Vein of Galen malformation, are also welcome. As such, this Special Issue welcomes submissions of original research and review articles related to any aspect of the molecular mechanisms and pathogenesis of cerebrovascular diseases, identification and exploration of novel targets, and biomarkers.
Prof. Dr. Anuska V. Andjelkovic
Prof. Dr. Richard F. Keep
Prof. Dr. Michael M. Wang
Manuscript Submission Information
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- cerebrovascular malformation
- small vessel diseases