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Special Issue "Molecular Research on Eryptosis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editors

Dr. Alessandro Attanzio
E-Mail Website
Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy
Interests: biochemistry; Sicilian foods; bioactive compounds; phytochemicals; bioactivity; cell cultures (colon, breast, cervix, liver, neuroblastoma); chemoprevention; oxidative stress; eryptosis
Special Issues and Collections in MDPI journals
Prof. Dr. Luisa Tesoriere
E-Mail Website
Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy
Interests: nutraceuticals; bioactivity of natural products; betalain pigments; biochemistry
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Eryptosis is defined as programmed cell death of red blood cells (RBCs). Similarly to apoptosis in nucleated cells, eryptosis is characterized by cell shrinkage, membrane blebbing and loss of membrane phospholipid asymmetry with phosphatidylserine exposure at the erythrocyte surface.

Eryptosis is a physiological process that allows senescent or damaged RBCs to be recognized and removed by macrophages preventing hemolysis and subsequent release of hemoglobin and pro-inflammatory cytosolic material into the bloodstream. It is triggered by several stressors such as hyperosmolarity, energy depletion, hyperthermia, oxidative stress and a wide variety of xenobiotics and endogenous compounds.

Excessive eryptosis is associated with several clinical conditions including atherosclerosis, atherothrombosis, iron deficiency, thalassemia, hemolytic uremic syndrome, myelodysplastic syndrome, cardiac and renal failure, Wilson’s disease, obesity, diabetes, chronic inflammatory diseases, malignancies, mycoplasma infection and malaria. In fact, since eryptotic RBCs can adhere to endothelial cells and thrombocytes compromising vascular microcirculation, it contributes to the complications associated with cardiometabolic and inflammatory diseases.

Investigating the effects of endogenous, natural or synthetic molecules in reducing erythrocyte death could provide novel insights into their possible use as protective agents in a variety of systemic diseases.

This special issue aims to collect original research articles and reviews that describe the molecular pathways of programmed erythrocyte death in the context of disease-related conditions.

Dr. Alessandro Attanzio
Prof. Dr. Luisa Tesoriere
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Eryptosis
  • Red blood cell
  • Senescence
  • Metabolic syndrome
  • Lifestyle
  • Antioxidants

Published Papers

This special issue is now open for submission.
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